{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye Y"],"funding":["Pearl River S and T Nova Program of Guangzhou","Natural Science Foundation of Guangdong Province"],"pagination":["44-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9059480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["The purpose of the present study is to evaluate the preparation and the structure of fraction OP-Ia and its protective effect against UV-induced photoaging through the MAPKs signaling pathway. Fractions OP-Ia and OP-Ib were prepared by enzymatic hydrolysis and purified by ultrafiltration (5 kDa) and gel chromatography (Sephadex G-25). The reducing power and superoxide radical scavenging ability were evaluated, which showed that OP-Ia had stronger antioxidant activity than OP-Ib. Next, ten peptides were identified in OP-Ia by UPLC-MS/MS. The mechanism of the anti-photoaging activity for fraction OP-Ia was investigated through the MAPKs pathway based on the HaCaT cell line. Fraction OP-Ia could inhibit the generation of ROS and the decline of cell viability induced by UV radiation, meanwhile"],"journal":["RSC advances"],"pubmed_title":["Preparation, structure identification and the anti-photoaging activity of peptide fraction OP-Ia from <i>Ostrea rivularis</i>."],"pmcid":["PMC9059480"],"funding_grant_id":["201610010096","2016A030312001"],"pubmed_authors":["You L","Li X","Zhao M","Deng Q","Ye Y"],"additional_accession":[]},"is_claimable":false,"name":"Preparation, structure identification and the anti-photoaging activity of peptide fraction OP-Ia from <i>Ostrea rivularis</i>.","description":"The purpose of the present study is to evaluate the preparation and the structure of fraction OP-Ia and its protective effect against UV-induced photoaging through the MAPKs signaling pathway. Fractions OP-Ia and OP-Ib were prepared by enzymatic hydrolysis and purified by ultrafiltration (5 kDa) and gel chromatography (Sephadex G-25). The reducing power and superoxide radical scavenging ability were evaluated, which showed that OP-Ia had stronger antioxidant activity than OP-Ib. Next, ten peptides were identified in OP-Ia by UPLC-MS/MS. The mechanism of the anti-photoaging activity for fraction OP-Ia was investigated through the MAPKs pathway based on the HaCaT cell line. Fraction OP-Ia could inhibit the generation of ROS and the decline of cell viability induced by UV radiation, meanwhile","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-19T09:54:17.256Z","creation":"2025-04-19T09:54:17.256Z"},"accession":"S-EPMC9059480","cross_references":{"pubmed":["35521595"],"doi":["10.1039/c8ra08137a"]}}