{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(1)"],"submitter":["Kirby L"],"pubmed_abstract":["<h4>Background</h4>Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epithelium to urine is involved in the pathogenesis of genital LS in males. This theory has not yet been robustly investigated in females.<h4>Objectives</h4>This review and meta-analysis examined whether there is an association between urinary incontinence (UI) and genital lichen LS in females.<h4>Methods</h4>We performed a comprehensive search of MEDLINE, Embase and CINAHL to identify observational studies assessing the prevalence of UI in females with LS. DerSimonian and Laird random-effects models were used to estimate the overall pooled pr"],"journal":["Skin health and disease"],"pagination":["e13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9060132"],"repository":["biostudies-literature"],"pubmed_title":["Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta-analysis."],"pmcid":["PMC9060132"],"pubmed_authors":["Simpson R","Kirby L","Gran S","Kreuser-Genis I","Owen C"],"additional_accession":[]},"is_claimable":false,"name":"Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta-analysis.","description":"<h4>Background</h4>Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epithelium to urine is involved in the pathogenesis of genital LS in males. This theory has not yet been robustly investigated in females.<h4>Objectives</h4>This review and meta-analysis examined whether there is an association between urinary incontinence (UI) and genital lichen LS in females.<h4>Methods</h4>We performed a comprehensive search of MEDLINE, Embase and CINAHL to identify observational studies assessing the prevalence of UI in females with LS. DerSimonian and Laird random-effects models were used to estimate the overall pooled pr","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T03:20:19.861Z","creation":"2025-04-04T03:20:19.861Z"},"accession":"S-EPMC9060132","cross_references":{"pubmed":["35664812"],"doi":["10.1002/ski2.13"]}}