biostudies-literatureUnknown9(6)Yao GDMSO was found to activate arylisothiocyanates for self-nucleophilic addition. A subsequent intramolecular C-H sulfurization catalyzed by PdBr₂ enables access to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C-H sulfurization of two isothiocyanates.RSC advances3403-3406https://www.ebi.ac.uk/biostudies/studies/S-EPMC9060301biostudies-literatureDMSO-mediated palladium-catalyzed cyclization of two isothiocyanates <i>via</i> C-H sulfurization: a new route to 2-aminobenzothiazoles.PMC9060301Wang BFZhang ZXYao GYang SXu HHTang RYfalseDMSO-mediated palladium-catalyzed cyclization of two isothiocyanates <i>via</i> C-H sulfurization: a new route to 2-aminobenzothiazoles.DMSO was found to activate arylisothiocyanates for self-nucleophilic addition. A subsequent intramolecular C-H sulfurization catalyzed by PdBr₂ enables access to a wide range of 2-aminobenzothiazole derivatives in moderate to good yields. This is the first example of a DMSO-mediated Pd-catalyzed synthesis of 2-aminobenzothiazoles through cyclization/C-H sulfurization of two isothiocyanates.2019-01-01T00:00:00Z2019 Jan2025-04-04T20:21:53.563Z2025-04-04T20:21:53.563ZS-EPMC90603013551894410.1039/c8ra09784d