{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martinho C"],"funding":["RCUK | Biotechnology and Biological Sciences Research Council"],"pagination":["e2112240119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9060480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(13)"],"pubmed_abstract":["SignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance of conspicuous phenotypes in maize but also in other plants and animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. It may be a consequence of wide-cross hybridization and may contribute to quantitative trait variation or unstable phenotypes in crops. Using the <i>sulfurea</i> (<i>sulf</i>) locus in tomato, we demonstrate that a self-reinforcing feedback loop involving DNA- and histone-methyl transferases CHROMOMETHYLTRANSFERASE3 (CMT3) and KRYPTONITE (KYP) is required for paramutation of <i>sulf</i> and that there is a change in chromatin organization. These findings advance t"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the <i>sulfurea</i> paramutation in <i>Solanum lycopersicum</i>."],"pmcid":["PMC9060480"],"funding_grant_id":["PDAG/387"],"pubmed_authors":["Buddle S","Ghigi A","Yarur A","Gouil Q","Muller S","Stam M","Barbour F","Liu C","Martinho C","Wang Z","Baulcombe DC"],"additional_accession":[]},"is_claimable":false,"name":"CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the <i>sulfurea</i> paramutation in <i>Solanum lycopersicum</i>.","description":"SignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance of conspicuous phenotypes in maize but also in other plants and animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. It may be a consequence of wide-cross hybridization and may contribute to quantitative trait variation or unstable phenotypes in crops. Using the <i>sulfurea</i> (<i>sulf</i>) locus in tomato, we demonstrate that a self-reinforcing feedback loop involving DNA- and histone-methyl transferases CHROMOMETHYLTRANSFERASE3 (CMT3) and KRYPTONITE (KYP) is required for paramutation of <i>sulf</i> and that there is a change in chromatin organization. These findings advance t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T21:33:27.715Z","creation":"2025-02-19T03:27:47.776Z"},"accession":"S-EPMC9060480","cross_references":{"pubmed":["35324329"],"doi":["10.1073/pnas.2112240119"]}}