biostudies-literatureWang TNational Natural Science Foundation of China5738-5741https://www.ebi.ac.uk/biostudies/studies/S-EPMC9060798biostudies-literatureUnknown9(10)N-heterocyclic carbene-palladium(ii)-catalyzed cross-coupling of benzylammonium salts with arylboronic acids for the synthesis of diarylmethane derivatives <i>via</i> C-N bond activation has been developed. Notably, in the presence of the easily prepared and bench-stable Pd-PEPPSI precatalyst, the Csp³-N bond activation of the benzylammonium salt even proceeded smoothly in isopropanol at room temperature.RSC advancesCross coupling of benzylammonium salts with boronic acids using a well-defined N-heterocyclic carbene-palladium(ii) precatalyst.PMC9060798U150420721572126Guo JLiu LJia DGuo HWang TWang XWang HfalseCross coupling of benzylammonium salts with boronic acids using a well-defined N-heterocyclic carbene-palladium(ii) precatalyst.N-heterocyclic carbene-palladium(ii)-catalyzed cross-coupling of benzylammonium salts with arylboronic acids for the synthesis of diarylmethane derivatives <i>via</i> C-N bond activation has been developed. Notably, in the presence of the easily prepared and bench-stable Pd-PEPPSI precatalyst, the Csp³-N bond activation of the benzylammonium salt even proceeded smoothly in isopropanol at room temperature.2019-01-01T00:00:00Z2019 Feb2025-04-04T23:17:16.857Z2025-04-04T23:17:16.857ZS-EPMC90607983551591710.1039/c8ra10439e