{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma W"],"funding":["Chinese Academy of Sciences","National Natural Science Foundation of China","University of Chinese Academy of Sciences"],"pagination":["7123-7127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9061063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(13)"],"pubmed_abstract":["Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-<i>b</i>]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh<sub>3</sub>)<sub>4</sub> and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K<sub>3</sub>PO<sub>4</sub>·3H<sub>2</sub>O as the base and <i>tert</i>-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates."],"journal":["RSC advances"],"pubmed_title":["One-pot synthesis and property study on thieno[3,2-<i>b</i>]furan compounds."],"pmcid":["PMC9061063"],"funding_grant_id":["21402194"],"pubmed_authors":["Jiang Y","Li C","Huang J","Qi T","Zhu X","Li B","Ma W"],"additional_accession":[]},"is_claimable":false,"name":"One-pot synthesis and property study on thieno[3,2-<i>b</i>]furan compounds.","description":"Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-<i>b</i>]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh<sub>3</sub>)<sub>4</sub> and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K<sub>3</sub>PO<sub>4</sub>·3H<sub>2</sub>O as the base and <i>tert</i>-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-04T23:17:29.43Z","creation":"2025-04-04T23:17:29.43Z"},"accession":"S-EPMC9061063","cross_references":{"pubmed":["35519975"],"doi":["10.1039/c9ra00796b"]}}