biostudies-literatureMa WChinese Academy of SciencesNational Natural Science Foundation of ChinaUniversity of Chinese Academy of Sciences7123-7127https://www.ebi.ac.uk/biostudies/studies/S-EPMC9061063biostudies-literatureUnknown9(13)Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-<i>b</i>]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh₃)₄ and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K₃PO₄·3H₂O as the base and <i>tert</i>-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates.RSC advancesOne-pot synthesis and property study on thieno[3,2-<i>b</i>]furan compounds.PMC906106321402194Jiang YLi CHuang JQi TZhu XLi BMa WfalseOne-pot synthesis and property study on thieno[3,2-<i>b</i>]furan compounds.Based on the regioselective intermolecular Suzuki coupling and subsequent intramolecular Ullmann C-O coupling reactions, one-pot synthesis of benzo[4,5]thieno[3,2-<i>b</i>]benzofurans (BTBFs) was developed after optimization of the reaction conditions including catalysts, solvents, bases, ligands and reaction times. The one-pot reaction, with only 2 mol% Pd(PPh₃)₄ and 2 mol% copper(i) thiophene-2-carboxylate (CuTc) as the catalysts, K₃PO₄·3H₂O as the base and <i>tert</i>-butanol as the solvent, afforded moderate to good yields (up to 70%) for a variety of substrates.2019-01-01T00:00:00Z2019 Mar2025-04-04T23:17:29.43Z2025-04-04T23:17:29.43ZS-EPMC90610633551997510.1039/c9ra00796b