{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(13)"],"submitter":["Xie D"],"pubmed_abstract":["A convenient method for the synthesis of 2-oxo-acetamidines from methyl ketones using aromatic amines and DMF as nitrogen sources is reported <i>via</i> copper-catalyzed C(sp<sup>3</sup>)-H amidination. Various methyl ketones react readily with aromatic amines and DMF, producing 2-oxo-acetamidines in yields of 47 to 92%. This protocol features the simultaneous formation of C-N and C[double bond, length as m-dash]N bonds using DMF and aromatic amines as two different nitrogen sources. It thus provides an efficient approach to construct acyclic amidines <i>via</i> three C(sp<sup>3</sup>)-H bond amidination. Based on the preliminary experiments, a plausible mechanism of this transformation is disclosed."],"journal":["RSC advances"],"pagination":["7203-7209"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9061129"],"repository":["biostudies-literature"],"pubmed_title":["Direct synthesis of 2-oxo-acetamidines from methyl ketones, aromatic amines and DMF <i>via</i> copper-catalyzed C(sp<sup>3</sup>)-H amidination."],"pmcid":["PMC9061129"],"pubmed_authors":["Xie D","Guo Y","He W","Xiao J","Liu Q","Guo C","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Direct synthesis of 2-oxo-acetamidines from methyl ketones, aromatic amines and DMF <i>via</i> copper-catalyzed C(sp<sup>3</sup>)-H amidination.","description":"A convenient method for the synthesis of 2-oxo-acetamidines from methyl ketones using aromatic amines and DMF as nitrogen sources is reported <i>via</i> copper-catalyzed C(sp<sup>3</sup>)-H amidination. Various methyl ketones react readily with aromatic amines and DMF, producing 2-oxo-acetamidines in yields of 47 to 92%. This protocol features the simultaneous formation of C-N and C[double bond, length as m-dash]N bonds using DMF and aromatic amines as two different nitrogen sources. It thus provides an efficient approach to construct acyclic amidines <i>via</i> three C(sp<sup>3</sup>)-H bond amidination. Based on the preliminary experiments, a plausible mechanism of this transformation is disclosed.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-04T07:43:05.941Z","creation":"2024-11-06T23:38:54.982Z"},"accession":"S-EPMC9061129","cross_references":{"pubmed":["35519951"],"doi":["10.1039/c9ra00616h"]}}