{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu C"],"funding":["National Natural Science Foundation of China"],"pagination":["8369-8372"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9062002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(15)"],"pubmed_abstract":["A novel and efficient copper-catalyzed synthesis of dihydro-6<i>H</i>-indolo[2,3-<i>b</i>]quinoline derivatives has been developed by using 3-alkyl-1-alkylindolin-2-imine hydrochlorides as the building blocks. Furthermore, easy reduction of dihydro-6<i>H</i>-indolo[2,3-<i>b</i>]quinolines with diisobutylaluminum hydride provided tetrahydro-6<i>H</i>-indolo[2,3-<i>b</i>]quinoline derivatives in excellent yields. The present method shows some advantages including use of cheap cuprous chloride as the catalyst and tolerance of wide functional groups."],"journal":["RSC advances"],"pubmed_title":["1-Alkyl-3-alkylindolin-2-imine hydrochlorides as useful building blocks in the copper-catalyzed synthesis of polycyclic indoline scaffolds."],"pmcid":["PMC9062002"],"funding_grant_id":["21772108"],"pubmed_authors":["Yang H","Fu H","Liu C","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"1-Alkyl-3-alkylindolin-2-imine hydrochlorides as useful building blocks in the copper-catalyzed synthesis of polycyclic indoline scaffolds.","description":"A novel and efficient copper-catalyzed synthesis of dihydro-6<i>H</i>-indolo[2,3-<i>b</i>]quinoline derivatives has been developed by using 3-alkyl-1-alkylindolin-2-imine hydrochlorides as the building blocks. Furthermore, easy reduction of dihydro-6<i>H</i>-indolo[2,3-<i>b</i>]quinolines with diisobutylaluminum hydride provided tetrahydro-6<i>H</i>-indolo[2,3-<i>b</i>]quinoline derivatives in excellent yields. The present method shows some advantages including use of cheap cuprous chloride as the catalyst and tolerance of wide functional groups.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-26T12:21:30.856Z","creation":"2025-04-06T13:55:36.153Z"},"accession":"S-EPMC9062002","cross_references":{"pubmed":["35518700"],"doi":["10.1039/c9ra00995g"]}}