{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhang L"],"pubmed_abstract":["Secreted peptide-mediated cell-to-cell communication plays a crucial role in the development of multicellular organisms. A large number of secreted peptides have been predicated by bioinformatic approaches in plants. However, only a few of them have been functionally characterized. In this study, we show that two CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) peptides CLE16/17 are required for both stem cell differentiation and lateral root (LR) emergence in <i>Arabidopsis</i>. We further demonstrate that the CLE16/17 peptides act through the CLAVATA1-ARABIDOPSIS CRINKLY4 (CLV1-ACR4) protein kinase complex in columella stem cell (CSC) differentiation, but not in LR emergence. Furthermore, we show that CLE16/17 promote LR emergence probably <i>via</i> activating the expression of <i>HAESA</i>/<i>HAESA-LIKE2</i> (<i>HAE</i>/<i>HSL2</i>) required for cell wall remodeling. Collectively, our results reveal a CLV1-ACR4-dependent and -independent dual-function of the CLE16/17 peptides in root development."],"journal":["Frontiers in plant science"],"pagination":["869888"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9062579"],"repository":["biostudies-literature"],"pubmed_title":["Control of Root Stem Cell Differentiation and Lateral Root Emergence by CLE16/17 Peptides in <i>Arabidopsis</i>."],"pmcid":["PMC9062579"],"pubmed_authors":["Pi L","Yang Y","Liu M","Zhu Y","Zhang L","Sawa S","Ishida T","Mu C"],"additional_accession":[]},"is_claimable":false,"name":"Control of Root Stem Cell Differentiation and Lateral Root Emergence by CLE16/17 Peptides in <i>Arabidopsis</i>.","description":"Secreted peptide-mediated cell-to-cell communication plays a crucial role in the development of multicellular organisms. A large number of secreted peptides have been predicated by bioinformatic approaches in plants. However, only a few of them have been functionally characterized. In this study, we show that two CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) peptides CLE16/17 are required for both stem cell differentiation and lateral root (LR) emergence in <i>Arabidopsis</i>. We further demonstrate that the CLE16/17 peptides act through the CLAVATA1-ARABIDOPSIS CRINKLY4 (CLV1-ACR4) protein kinase complex in columella stem cell (CSC) differentiation, but not in LR emergence. Furthermore, we show that CLE16/17 promote LR emergence probably <i>via</i> activating the expression of <i>HAESA</i>/<i>HAESA-LIKE2</i> (<i>HAE</i>/<i>HSL2</i>) required for cell wall remodeling. Collectively, our results reveal a CLV1-ACR4-dependent and -independent dual-function of the CLE16/17 peptides in root development.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T18:01:02.463Z","creation":"2025-04-25T18:01:02.463Z"},"accession":"S-EPMC9062579","cross_references":{"pubmed":["35519820"],"doi":["10.3389/fpls.2022.869888"]}}