biostudies-literatureUnknown34van der Horn HJSpinocerebellar ataxia type 3 (SCA3) is a rare genetic neurodegenerative disease. The neurobiological basis of SCA3 is still poorly understood, and up until now resting-state fMRI (rs-fMRI) has not been used to study this disease. In the current study we investigated (multi-echo) rs-fMRI data from patients with genetically confirmed SCA3 (n = 17) and matched healthy subjects (n = 16). Using independent component analysis (ICA) and subsequent regression with bootstrap resampling, we identified a pattern of differences between patients and healthy subjects, which we coined the fMRI SCA3 related pattern (fSCA3-RP) comprising cerebellum, anterior striatum and various cortical regions. Individual fSCA3-RP scores were highly correlated with a previously published ¹⁸F-FDG PET pattern fNeuroImage. Clinical103023https://www.ebi.ac.uk/biostudies/studies/S-EPMC9062756biostudies-literatureA resting-state fMRI pattern of spinocerebellar ataxia type 3 and comparison with ¹⁸F-FDG PET.PMC9062756Vergara VMSpikman JMMeles SKvan der Horn HJQi SDe Jong BMRenken RJKremer HPHCalhoun VDde Vries JJKok JGDalenberg JRSiero JCWfalseA resting-state fMRI pattern of spinocerebellar ataxia type 3 and comparison with ¹⁸F-FDG PET.Spinocerebellar ataxia type 3 (SCA3) is a rare genetic neurodegenerative disease. The neurobiological basis of SCA3 is still poorly understood, and up until now resting-state fMRI (rs-fMRI) has not been used to study this disease. In the current study we investigated (multi-echo) rs-fMRI data from patients with genetically confirmed SCA3 (n = 17) and matched healthy subjects (n = 16). Using independent component analysis (ICA) and subsequent regression with bootstrap resampling, we identified a pattern of differences between patients and healthy subjects, which we coined the fMRI SCA3 related pattern (fSCA3-RP) comprising cerebellum, anterior striatum and various cortical regions. Individual fSCA3-RP scores were highly correlated with a previously published ¹⁸F-FDG PET pattern f2022-01-01T00:00:00Z20222025-04-25T18:06:16.217Z2025-04-25T18:06:16.217ZS-EPMC90627563548919310.1016/j.nicl.2022.103023