{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shlipak MG"],"funding":["NCATS NIH HHS","NIA NIH HHS","NIDDK NIH HHS"],"pagination":["650-659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9062767"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["182(6)"],"pubmed_abstract":["<h4>Importance</h4>Observational evidence suggests that higher physical activity is associated with slower kidney function decline; however, to our knowledge, no large trial has evaluated whether activity and exercise can ameliorate kidney function decline in older adults.<h4>Objective</h4>To evaluate whether a moderate-intensity exercise intervention can affect the rate of estimated glomerular filtration rate per cystatin C (eGFRCysC) change in older adults.<h4>Design, setting, and participants</h4>This ancillary analysis of the Lifestyle Interventions and Independence For Elders randomized clinical trial enrolled 1199 community-dwelling, sedentary adults aged 70 to 89 years with mobility limitations and available blood specimens. The original trial was conducted across 8 academic centers"],"journal":["JAMA internal medicine"],"pubmed_title":["Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults: An Ancillary Analysis of the LIFE Study Randomized Clinical Trial."],"pmcid":["PMC9062767"],"funding_grant_id":["R01 DK115562","U01 AG022376","UL1 TR003142","R03 AG067981","K23 AG057813"],"pubmed_authors":["Coca SG","Reid KF","Rodarte R","Williams K","Knaggs JD","Espeland MA","McGucken A","Harvin LN","Stafford RS","Marsiske M","Chupp GL","Miller ME","Vaz Fragoso CA","Walkup MP","Bonds D","Goodpaster BH","Hankinson JL","Kim WS","Newman AB","Kashaf SS","Myers VH","Buford TW","Rushing J","Pahor M","Sandesara BD","Kritchevsky SB","Wrights A","Cook D","Rushing S","Bugaj JA","Mignosa BM","Kirn DR","Spring B","Jotwani V","Hauser J","Halpin SN","Rapp SR","Zenoni MA","Butitta BP","Pruitt LA","Roberson W","Morris HL","Castro CM","Pepine CJ","Graff R","Iannone LP","Bonk JT","Wu KC","Lopez O","Pasha EP","Donatto S","Lu CJ","Hadley EC","Shertzer-Skinner R","Henkin L","Marsh AP","Folta SC","Beard VE","Deluca D","Axtell RS","Causer J","Leeuwenburgh C","Sweeney Barnett T","Handberg E","Beavers DP","Szady A","Blair SN","Grove G","Tsiroyannis EX","Verghese J","Domanchuk K","Barr D","Brennan MJ","Rego A","Fitch M","Shepard DM","Tranah G","Fennelly B","Radcliff KA","Jennings JM","Hendrie HC","Wilson VK","Leeuwenburgh J","Rejeski WJ","Millet HK","Gill TM","Brubaker PH","Nayfield S","Romashkan S","Jennings J","Woolard N","Tudor-Locke C","Sheshadri A","Fielding RA","Lorow MS","Nadkarni NK","Groessl EJ","McGloin JM","Anton SD","Hsu FC","Byington RP","Furberg CD","Kost P","Hepler J","Ix J","Hill J","Korytov I","Ariet M","Shlipak MG","Ambrosius WT","Newman MA","Britt NE","Patel KV","McDavitt EC","Brinkley TE","Fries R","Manini TM","Kennedy K","Singletary FF","Kaplan RM","Yank V","McDermott MM","Applegate W","Crump L","Berra K","Hau C","Chen SH","Liu CK","Flynn GM","LIFE Investigators","Church TS","Nelson ME","Mautner R","Ives DG","Marena WC","Stowe CL","Haskell WL","Demons JS","Glynn NW","Kerwin D","Katula JA","Williamson J","Mihalko SL","Holmes L","Hire D","Harris M","Lovato L","Espeland M","Monce R","Phillips EM","Caudle C","Cocreham SH","Studenski SA","King AC","Guralnik JM","Sink KM","de Rekeneire N"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults: An Ancillary Analysis of the LIFE Study Randomized Clinical Trial.","description":"<h4>Importance</h4>Observational evidence suggests that higher physical activity is associated with slower kidney function decline; however, to our knowledge, no large trial has evaluated whether activity and exercise can ameliorate kidney function decline in older adults.<h4>Objective</h4>To evaluate whether a moderate-intensity exercise intervention can affect the rate of estimated glomerular filtration rate per cystatin C (eGFRCysC) change in older adults.<h4>Design, setting, and participants</h4>This ancillary analysis of the Lifestyle Interventions and Independence For Elders randomized clinical trial enrolled 1199 community-dwelling, sedentary adults aged 70 to 89 years with mobility limitations and available blood specimens. The original trial was conducted across 8 academic centers","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-09T13:51:34.905Z","creation":"2025-04-05T00:17:01.838Z"},"accession":"S-EPMC9062767","cross_references":{"pubmed":["35499834"],"doi":["10.1001/jamainternmed.2022.1449"]}}