biostudies-literatureShlipak MGNCATS NIH HHSNIA NIH HHSNIDDK NIH HHS650-659https://www.ebi.ac.uk/biostudies/studies/S-EPMC9062767biostudies-literatureUnknown182(6)<h4>Importance</h4>Observational evidence suggests that higher physical activity is associated with slower kidney function decline; however, to our knowledge, no large trial has evaluated whether activity and exercise can ameliorate kidney function decline in older adults.<h4>Objective</h4>To evaluate whether a moderate-intensity exercise intervention can affect the rate of estimated glomerular filtration rate per cystatin C (eGFRCysC) change in older adults.<h4>Design, setting, and participants</h4>This ancillary analysis of the Lifestyle Interventions and Independence For Elders randomized clinical trial enrolled 1199 community-dwelling, sedentary adults aged 70 to 89 years with mobility limitations and available blood specimens. The original trial was conducted across 8 academic centersJAMA internal medicineEffect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults: An Ancillary Analysis of the LIFE Study Randomized Clinical Trial.PMC9062767R01 DK115562U01 AG022376UL1 TR003142R03 AG067981K23 AG057813Coca SGReid KFRodarte RWilliams KKnaggs JDEspeland MAMcGucken AHarvin LNStafford RSMarsiske MChupp GLMiller MEVaz Fragoso CAWalkup MPBonds DGoodpaster BHHankinson JLKim WSNewman ABKashaf SSMyers VHBuford TWRushing JPahor MSandesara BDKritchevsky SBWrights ACook DRushing SBugaj JAMignosa BMKirn DRSpring BJotwani VHauser JHalpin SNRapp SRZenoni MAButitta BPPruitt LARoberson WMorris HLCastro CMPepine CJGraff RIannone LPBonk JTWu KCLopez OPasha EPDonatto SLu CJHadley ECShertzer-Skinner RHenkin LMarsh APFolta SCBeard VEDeluca DAxtell RSCauser JLeeuwenburgh CSweeney Barnett THandberg EBeavers DPSzady ABlair SNGrove GTsiroyannis EXVerghese JDomanchuk KBarr DBrennan MJRego AFitch MShepard DMTranah GFennelly BRadcliff KAJennings JMHendrie HCWilson VKLeeuwenburgh JRejeski WJMillet HKGill TMBrubaker PHNayfield SRomashkan SJennings JWoolard NTudor-Locke CSheshadri AFielding RALorow MSNadkarni NKGroessl EJMcGloin JMAnton SDHsu FCByington RPFurberg CDKost PHepler JIx JHill JKorytov IAriet MShlipak MGAmbrosius WTNewman MABritt NEPatel KVMcDavitt ECBrinkley TEFries RManini TMKennedy KSingletary FFKaplan RMYank VMcDermott MMApplegate WCrump LBerra KHau CChen SHLiu CKFlynn GMLIFE InvestigatorsChurch TSNelson MEMautner RIves DGMarena WCStowe CLHaskell WLDemons JSGlynn NWKerwin DKatula JAWilliamson JMihalko SLHolmes LHire DHarris MLovato LEspeland MMonce RPhillips EMCaudle CCocreham SHStudenski SAKing ACGuralnik JMSink KMde Rekeneire NfalseEffect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults: An Ancillary Analysis of the LIFE Study Randomized Clinical Trial.<h4>Importance</h4>Observational evidence suggests that higher physical activity is associated with slower kidney function decline; however, to our knowledge, no large trial has evaluated whether activity and exercise can ameliorate kidney function decline in older adults.<h4>Objective</h4>To evaluate whether a moderate-intensity exercise intervention can affect the rate of estimated glomerular filtration rate per cystatin C (eGFRCysC) change in older adults.<h4>Design, setting, and participants</h4>This ancillary analysis of the Lifestyle Interventions and Independence For Elders randomized clinical trial enrolled 1199 community-dwelling, sedentary adults aged 70 to 89 years with mobility limitations and available blood specimens. The original trial was conducted across 8 academic centers2022-01-01T00:00:00Z2022 Jun2026-05-09T13:51:34.905Z2025-04-05T00:17:01.838ZS-EPMC90627673549983410.1001/jamainternmed.2022.1449