biostudies-literatureNellis MUNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCESUniversity of Texas Medical Branch Center for Environmental ToxicologyNCATS NIH HHSEMORY UNIVERSITYBrown FoundationNIEHS NIH HHSNational Institutes of HealthHealth Effects InstituteArkansas Biosciences Institute152987https://www.ebi.ac.uk/biostudies/studies/S-EPMC9062885biostudies-literatureUnknown4631,3-Butadiene (BD) exposure is known to cause numerous adverse health effects, including cancer, in animals and humans. BD is metabolized to reactive epoxide intermediates, which are genotoxic, but it is not well know what other effects BD has on cellular metabolism. We examined the effects of exposure to BD on the mouse lung metabolome in the genetically heterogeneous collaborative cross outbred mouse model. Mice were exposed to 3 concentra-tions of BD for 10 days (2, 20, and 200 ppm), and lung tissues were analyzed using high-resolution mass spectrometry-based metabolomics. As compared to controls (0 ppm BD), BD had extensive effects on lung metabolism at all concentrations of exposure, including the lowest concentration of 2 ppm, as reflected by reprogramming of multiple metabolic pathwToxicologyLung metabolome of 1,3-butadiene exposed Collaborative Cross mice reflects metabolic phenotype of human lung cancer.PMC9062885P30ES019776UL1TR000039R21ES019684UL1 TR000039T32 ES007254P30 ES030285R21ES023046R21 ES019684P30 ES019776HEI4907-RFPA09-5/12-1R21 ES031824R21 ES023046R21ES031824T32ES007254F32 ES013107Nellis MLiu KCaperton COHallberg LMAmeredes BTJones DPGo YMBoysen GTran VfalseLung metabolome of 1,3-butadiene exposed Collaborative Cross mice reflects metabolic phenotype of human lung cancer.1,3-Butadiene (BD) exposure is known to cause numerous adverse health effects, including cancer, in animals and humans. BD is metabolized to reactive epoxide intermediates, which are genotoxic, but it is not well know what other effects BD has on cellular metabolism. We examined the effects of exposure to BD on the mouse lung metabolome in the genetically heterogeneous collaborative cross outbred mouse model. Mice were exposed to 3 concentra-tions of BD for 10 days (2, 20, and 200 ppm), and lung tissues were analyzed using high-resolution mass spectrometry-based metabolomics. As compared to controls (0 ppm BD), BD had extensive effects on lung metabolism at all concentrations of exposure, including the lowest concentration of 2 ppm, as reflected by reprogramming of multiple metabolic pathw2021-01-01T00:00:00Z2021 Nov2025-04-18T13:24:10.508Z2025-02-19T01:30:39.001ZS-EPMC90628853464887010.1016/j.tox.2021.152987