{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu G"],"funding":["National Natural Science Foundation of China"],"pagination":["11142-11150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9063016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(20)"],"pubmed_abstract":["10,11-Methylenedioxy-camptothecin (FL118) is a novel camptothecin analogue that possesses exceptional antitumor efficacy in human tumor xenograft models. The aim of the current study was to develop novel 20-substituted FL118 derivatives coupled with glycosyl-succinic acid esters with improved antitumor efficacy. These FL118 glycoside derivatives were designed, synthesized and their cytotoxicity evaluated in three tumor cell lines (A-549, MDA-MB-231 and RM-1). All of the derivatives showed superior <i>in vitro</i> cytotoxic activity and were more potent than irinotecan in A549 and MDA-MB-231 cells. In mouse prostate cancer cells RM-1, 10,11-methylenedioxy-camptothecin rhamnoside 11b displayed significant activities with IC<sub>50</sub> of 48.27 nM. Western blot analysis demonstrated that 11"],"journal":["RSC advances"],"pubmed_title":["Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects <i>in vivo</i>."],"pmcid":["PMC9063016"],"funding_grant_id":["U1406403","U1706213"],"pubmed_authors":["Yu R","Dong X","Mai X","Xu Q","Zhang L","Jiang T","Wu G","Hao C","Liu F","Lin M"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects <i>in vivo</i>.","description":"10,11-Methylenedioxy-camptothecin (FL118) is a novel camptothecin analogue that possesses exceptional antitumor efficacy in human tumor xenograft models. The aim of the current study was to develop novel 20-substituted FL118 derivatives coupled with glycosyl-succinic acid esters with improved antitumor efficacy. These FL118 glycoside derivatives were designed, synthesized and their cytotoxicity evaluated in three tumor cell lines (A-549, MDA-MB-231 and RM-1). All of the derivatives showed superior <i>in vitro</i> cytotoxic activity and were more potent than irinotecan in A549 and MDA-MB-231 cells. In mouse prostate cancer cells RM-1, 10,11-methylenedioxy-camptothecin rhamnoside 11b displayed significant activities with IC<sub>50</sub> of 48.27 nM. Western blot analysis demonstrated that 11","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-05-31T09:47:46.605Z","creation":"2025-02-18T23:57:24.656Z"},"accession":"S-EPMC9063016","cross_references":{"pubmed":["35520228"],"doi":["10.1039/c9ra00315k"]}}