{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Tang M"],"pubmed_abstract":["<h4>Objective</h4>To investigate the clinicopathological features, and mutations of NRAS, KRAS, BRAF and MAP2K1 genes in extranodal Rosai-Dorfman disease (RDD).<h4>Methods</h4>The clinic opathological features of 27 patients with extranodal RDD were retrospectively analyzed, and the NRAS, KRAS, BRAF and MAP2K1 genes mutation were detected by Sanger sequencing.<h4>Results</h4>The male to female ratio was 1.7:1. The average age was 46.9 years. There were skin lesions in 12 cases (44.4%) and head and neck lesions in 8 cases (29.6%). Microscopically, those patients with skin RDD had lesions characterized by clear and dark intervals and obvious emperipolesis, while in other parts, the background was more complex. About 21.1% (4/19) had mutations, including 3 mutations in NRAS 2 exon and 1 mutat"],"journal":["Journal of inflammation research"],"pagination":["2775-2787"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064053"],"repository":["biostudies-literature"],"pubmed_title":["Clinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai-Dorfman Disease."],"pmcid":["PMC9064053"],"pubmed_authors":["Tang M","Yang XT","Gu XZ","Wu PC"],"additional_accession":[]},"is_claimable":false,"name":"Clinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai-Dorfman Disease.","description":"<h4>Objective</h4>To investigate the clinicopathological features, and mutations of NRAS, KRAS, BRAF and MAP2K1 genes in extranodal Rosai-Dorfman disease (RDD).<h4>Methods</h4>The clinic opathological features of 27 patients with extranodal RDD were retrospectively analyzed, and the NRAS, KRAS, BRAF and MAP2K1 genes mutation were detected by Sanger sequencing.<h4>Results</h4>The male to female ratio was 1.7:1. The average age was 46.9 years. There were skin lesions in 12 cases (44.4%) and head and neck lesions in 8 cases (29.6%). Microscopically, those patients with skin RDD had lesions characterized by clear and dark intervals and obvious emperipolesis, while in other parts, the background was more complex. About 21.1% (4/19) had mutations, including 3 mutations in NRAS 2 exon and 1 mutat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-18T12:05:28.321Z","creation":"2025-04-05T20:38:56.561Z"},"accession":"S-EPMC9064053","cross_references":{"pubmed":["35518839"],"doi":["10.2147/JIR.S365098"]}}