biostudies-literatureUnknown15Tang M<h4>Objective</h4>To investigate the clinicopathological features, and mutations of NRAS, KRAS, BRAF and MAP2K1 genes in extranodal Rosai-Dorfman disease (RDD).<h4>Methods</h4>The clinic opathological features of 27 patients with extranodal RDD were retrospectively analyzed, and the NRAS, KRAS, BRAF and MAP2K1 genes mutation were detected by Sanger sequencing.<h4>Results</h4>The male to female ratio was 1.7:1. The average age was 46.9 years. There were skin lesions in 12 cases (44.4%) and head and neck lesions in 8 cases (29.6%). Microscopically, those patients with skin RDD had lesions characterized by clear and dark intervals and obvious emperipolesis, while in other parts, the background was more complex. About 21.1% (4/19) had mutations, including 3 mutations in NRAS 2 exon and 1 mutatJournal of inflammation research2775-2787https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064053biostudies-literatureClinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai-Dorfman Disease.PMC9064053Tang MYang XTGu XZWu PCfalseClinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai-Dorfman Disease.<h4>Objective</h4>To investigate the clinicopathological features, and mutations of NRAS, KRAS, BRAF and MAP2K1 genes in extranodal Rosai-Dorfman disease (RDD).<h4>Methods</h4>The clinic opathological features of 27 patients with extranodal RDD were retrospectively analyzed, and the NRAS, KRAS, BRAF and MAP2K1 genes mutation were detected by Sanger sequencing.<h4>Results</h4>The male to female ratio was 1.7:1. The average age was 46.9 years. There were skin lesions in 12 cases (44.4%) and head and neck lesions in 8 cases (29.6%). Microscopically, those patients with skin RDD had lesions characterized by clear and dark intervals and obvious emperipolesis, while in other parts, the background was more complex. About 21.1% (4/19) had mutations, including 3 mutations in NRAS 2 exon and 1 mutat2022-01-01T00:00:00Z20222025-05-18T12:05:28.321Z2025-04-05T20:38:56.561ZS-EPMC90640533551883910.2147/JIR.S365098