{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martin CA"],"funding":["Instituto de Salud Carlos III","Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina","Ministerio de Economía y Competitividad","Department of Biotechnology, Ministry of Science and Technology","European Regional Development Fund"],"pagination":["14452-14464"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064131"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(25)"],"pubmed_abstract":["Neural tissue engineering aims at producing a simulated environment using a matrix that is suitable to grow specialized neurons/glial cells pertaining to CNS/PNS which replace damaged or lost tissues. The primary goal of this study is to design a compatible scaffold that supports the development of neural-lineage cells which aids in neural regeneration. The fabricated, freeze-dried scaffolds consisted of biocompatible, natural and synthetic polymers: gelatin and polyvinyl pyrrolidone. Physiochemical characterization was carried out using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) imaging. The 3D construct retains good swelling proficiency and holds the integrated structure that supports cell adhesion and proliferation. The composite of PVP-gelati"],"journal":["RSC advances"],"pubmed_title":["An innovative bioresorbable gelatin based 3D scaffold that maintains the stemness of adipose tissue derived stem cells and the plasticity of differentiated neurons."],"pmcid":["PMC9064131"],"funding_grant_id":["BCIL/NER-BPMC/2014-1094","SR/WOS-A/ LS-193/2012","MAT2016-76039-C4-1-R"],"pubmed_authors":["Duenas JMM","Nagarajan S","Sellathamby S","Lakshmi BS","Subbaraya NK","E A K N","Reddy MS","Muthukoori S","Martin CA","Rela M","Gomez-Tejedor JA","Gomez Ribelles JL","Radhakrishnan S"],"additional_accession":[]},"is_claimable":false,"name":"An innovative bioresorbable gelatin based 3D scaffold that maintains the stemness of adipose tissue derived stem cells and the plasticity of differentiated neurons.","description":"Neural tissue engineering aims at producing a simulated environment using a matrix that is suitable to grow specialized neurons/glial cells pertaining to CNS/PNS which replace damaged or lost tissues. The primary goal of this study is to design a compatible scaffold that supports the development of neural-lineage cells which aids in neural regeneration. The fabricated, freeze-dried scaffolds consisted of biocompatible, natural and synthetic polymers: gelatin and polyvinyl pyrrolidone. Physiochemical characterization was carried out using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) imaging. The 3D construct retains good swelling proficiency and holds the integrated structure that supports cell adhesion and proliferation. The composite of PVP-gelati","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2025-04-18T12:13:50.892Z","creation":"2025-04-06T21:51:39.172Z"},"accession":"S-EPMC9064131","cross_references":{"pubmed":["35519343"],"doi":["10.1039/c8ra09688k"]}}