biostudies-literatureMartin CAInstituto de Salud Carlos IIICentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y NanomedicinaMinisterio de Economía y CompetitividadDepartment of Biotechnology, Ministry of Science and TechnologyEuropean Regional Development Fund14452-14464https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064131biostudies-literatureUnknown9(25)Neural tissue engineering aims at producing a simulated environment using a matrix that is suitable to grow specialized neurons/glial cells pertaining to CNS/PNS which replace damaged or lost tissues. The primary goal of this study is to design a compatible scaffold that supports the development of neural-lineage cells which aids in neural regeneration. The fabricated, freeze-dried scaffolds consisted of biocompatible, natural and synthetic polymers: gelatin and polyvinyl pyrrolidone. Physiochemical characterization was carried out using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) imaging. The 3D construct retains good swelling proficiency and holds the integrated structure that supports cell adhesion and proliferation. The composite of PVP-gelatiRSC advancesAn innovative bioresorbable gelatin based 3D scaffold that maintains the stemness of adipose tissue derived stem cells and the plasticity of differentiated neurons.PMC9064131BCIL/NER-BPMC/2014-1094SR/WOS-A/ LS-193/2012MAT2016-76039-C4-1-RDuenas JMMNagarajan SSellathamby SLakshmi BSSubbaraya NKE A K NReddy MSMuthukoori SMartin CARela MGomez-Tejedor JAGomez Ribelles JLRadhakrishnan SfalseAn innovative bioresorbable gelatin based 3D scaffold that maintains the stemness of adipose tissue derived stem cells and the plasticity of differentiated neurons.Neural tissue engineering aims at producing a simulated environment using a matrix that is suitable to grow specialized neurons/glial cells pertaining to CNS/PNS which replace damaged or lost tissues. The primary goal of this study is to design a compatible scaffold that supports the development of neural-lineage cells which aids in neural regeneration. The fabricated, freeze-dried scaffolds consisted of biocompatible, natural and synthetic polymers: gelatin and polyvinyl pyrrolidone. Physiochemical characterization was carried out using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) imaging. The 3D construct retains good swelling proficiency and holds the integrated structure that supports cell adhesion and proliferation. The composite of PVP-gelati2019-01-01T00:00:00Z2019 May2025-04-18T12:13:50.892Z2025-04-06T21:51:39.172ZS-EPMC90641313551934310.1039/c8ra09688k