biostudies-literatureLiu BGansu Agricultural UniversityMinistry of Science and Technology of the People&apos;s Republic of ChinaBeijing Nova ProgramNational Natural Science Foundation of China14966-14973https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064222biostudies-literatureUnknown9(26)Celluloses are renewable and biodegradable natural resources. The application of celluloses as oil-in-water Pickering emulsifiers is still quite limited. In this paper, cellulose nanofibrils (CNFs) with oxidation degrees (DOs) of 52.8% and 92.7% (DO50 and DO90) were obtained from TEMPO-mediate oxidation for microcrystalline cellulose (MC). The production of carboxyl groups of CNFs were confirmed by FT-IR and ¹³C solid-NMR. CNF-stabilized O/W Pickering emulsion showed excellent colloidal stability compared with un-oxidized cellulose by Turbiscan stability analysis. Additionally, CNF-stabilized Pickering emulsions showed stable colloidal properties in simulated intestinal fluid (SIF). Most importantly, <i>in vitro</i> fatty acid release kinetics under SIF showed that CNFs have strRSC advancesInhibition of oil digestion in Pickering emulsions stabilized by oxidized cellulose nanofibrils for low-calorie food design.PMC90642222016YFD0400804Z181100006218071NSFC 31471577, 31772014Gaufx-02Y01Tian JLi YZhu YLi DGuan TWen PLiu BBao CNorde WfalseInhibition of oil digestion in Pickering emulsions stabilized by oxidized cellulose nanofibrils for low-calorie food design.Celluloses are renewable and biodegradable natural resources. The application of celluloses as oil-in-water Pickering emulsifiers is still quite limited. In this paper, cellulose nanofibrils (CNFs) with oxidation degrees (DOs) of 52.8% and 92.7% (DO50 and DO90) were obtained from TEMPO-mediate oxidation for microcrystalline cellulose (MC). The production of carboxyl groups of CNFs were confirmed by FT-IR and ¹³C solid-NMR. CNF-stabilized O/W Pickering emulsion showed excellent colloidal stability compared with un-oxidized cellulose by Turbiscan stability analysis. Additionally, CNF-stabilized Pickering emulsions showed stable colloidal properties in simulated intestinal fluid (SIF). Most importantly, <i>in vitro</i> fatty acid release kinetics under SIF showed that CNFs have str2019-01-01T00:00:00Z2019 May2025-04-04T12:43:31.607Z2025-04-04T12:43:31.607ZS-EPMC90642223551632610.1039/c9ra02417d