biostudies-literatureCao LPriority Academic Program Development of Jiangsu Higher Education InstitutionsNational Natural Science Foundation of China15307-15313https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064256biostudies-literatureUnknown9(27)This work reports the first construction of the ternary layers of ITO/PbS/SiO₂/AuNPs nanostructure for development of photoelectrochemical (PEC) glucose sensor. Herein, the thioglycolic acid-capped PbS quantum dots was employed as a PEC active probe, which is very sensitive to oxygen. The small gold nanoparticles (AuNPs) were act as nanozyme (mimic enzyme of glucose oxidase) to catalytically oxidize glucose in the presence of oxygen, meanwhile consumed oxygen and then resulted in the decrease of cathodic photocurrent. The insertion layer of SiO₂ nanoparticles between PbS and AuNPs could reduce efficiently the base current due to its low electroconductivity, which improved the detection limit. The proposed PEC sensor exhibited high sensitivity and gold selectivity towaRSC advancesA photoelectrochemical glucose sensor based on gold nanoparticles as a mimic enzyme of glucose oxidase.PMC906425621475092Cao LWang PChen LWu YDi JfalseA photoelectrochemical glucose sensor based on gold nanoparticles as a mimic enzyme of glucose oxidase.This work reports the first construction of the ternary layers of ITO/PbS/SiO₂/AuNPs nanostructure for development of photoelectrochemical (PEC) glucose sensor. Herein, the thioglycolic acid-capped PbS quantum dots was employed as a PEC active probe, which is very sensitive to oxygen. The small gold nanoparticles (AuNPs) were act as nanozyme (mimic enzyme of glucose oxidase) to catalytically oxidize glucose in the presence of oxygen, meanwhile consumed oxygen and then resulted in the decrease of cathodic photocurrent. The insertion layer of SiO₂ nanoparticles between PbS and AuNPs could reduce efficiently the base current due to its low electroconductivity, which improved the detection limit. The proposed PEC sensor exhibited high sensitivity and gold selectivity towa2019-01-01T00:00:00Z2019 May2025-04-04T12:44:06.769Z2025-04-04T12:44:06.769ZS-EPMC90642563551483610.1039/c9ra02088h