biostudies-literatureFayez SDeutscher Akademischer Austauschdienst, DAADDeutsche Forschungsgemeinschaft15738-15748https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064271biostudies-literatureUnknown9(28)A unique series of six biaryl natural products displaying four different coupling types (5,1', 7,1', 7,8', and 5,8') were isolated from the roots of the West African liana <i>Ancistrocladus abbreviatus</i> (Ancistrocladaceae). Although at first sight structurally diverse, these secondary metabolites all have in common that they belong to the rare group of naphthylisoquinoline alkaloids with a fully dehydrogenated isoquinoline portion. Among the African <i>Ancistrocladus</i> species, <i>A. abbreviatus</i> is so far only the second one that was found to produce compounds with such a molecular entity. Here, we report on four new representatives, named ancistrobreveines A-D (12-14, and 6). They were identified along with the two known alkaloids 6-<i>O</i>-methylhamateine (4) and <i>ent</i>-dioRSC advancesAncistrobreveines A-D and related dehydrogenated naphthylisoquinoline alkaloids with antiproliferative activities against leukemia cells, from the West African liana <i>Ancistrocladus abbreviatus</i>.PMC9064271to Shaimaa FayezSFB 630Br699/14-2Efferth TBringmann GFayez SAssi LASeo EJFeineis DfalseAncistrobreveines A-D and related dehydrogenated naphthylisoquinoline alkaloids with antiproliferative activities against leukemia cells, from the West African liana <i>Ancistrocladus abbreviatus</i>.A unique series of six biaryl natural products displaying four different coupling types (5,1', 7,1', 7,8', and 5,8') were isolated from the roots of the West African liana <i>Ancistrocladus abbreviatus</i> (Ancistrocladaceae). Although at first sight structurally diverse, these secondary metabolites all have in common that they belong to the rare group of naphthylisoquinoline alkaloids with a fully dehydrogenated isoquinoline portion. Among the African <i>Ancistrocladus</i> species, <i>A. abbreviatus</i> is so far only the second one that was found to produce compounds with such a molecular entity. Here, we report on four new representatives, named ancistrobreveines A-D (12-14, and 6). They were identified along with the two known alkaloids 6-<i>O</i>-methylhamateine (4) and <i>ent</i>-dio2019-01-01T00:00:00Z2019 May2025-04-04T12:43:31.018Z2025-04-04T12:43:31.018ZS-EPMC90642713552137510.1039/c9ra03105g