biostudies-literatureUnknown9(31)Gadde KUniversiteit AntwerpenFonds Wetenschappelijk OnderzoekThe iron(iii)-catalyzed efficient strategy for the synthesis of α-substituted homoallylamines was accomplished <i>via</i> a cationic 2-aza-Cope rearrangement of aldimines, generated <i>in situ</i> by condensation of commercially available aldehydes and easily synthesizable 1,1-diphenylhomoallylamines. This reaction features a broad substrate scope with high yields and is conducted in an eco-friendly solvent, <i>i.e.</i> dimethyl carbonate.RSC advances18013-18017https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064679biostudies-literatureLewis acidic FeCl₃ promoted 2-aza-Cope rearrangement to afford α-substituted homoallylamines in dimethyl carbonate.PMC9064679Maes BUWGadde KDaelemans JAbbaspour Tehrani KfalseLewis acidic FeCl₃ promoted 2-aza-Cope rearrangement to afford α-substituted homoallylamines in dimethyl carbonate.The iron(iii)-catalyzed efficient strategy for the synthesis of α-substituted homoallylamines was accomplished <i>via</i> a cationic 2-aza-Cope rearrangement of aldimines, generated <i>in situ</i> by condensation of commercially available aldehydes and easily synthesizable 1,1-diphenylhomoallylamines. This reaction features a broad substrate scope with high yields and is conducted in an eco-friendly solvent, <i>i.e.</i> dimethyl carbonate.2019-01-01T00:00:00Z2019 Jun2025-04-04T20:21:51.693Z2025-04-04T20:21:51.693ZS-EPMC90646793552054710.1039/c9ra03277k