{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee CD"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","National Institutes of Health","NIAID","NIDDK","NIGMS NIH HHS","NIGMS"],"pagination":["32-38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9064876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["66"],"pubmed_abstract":["As an anaerobe, Clostridioides difficile relies on the formation of a dormant spore for survival outside of the mammalian host's gastrointestinal tract. The spore is recalcitrant to desiccation, numerous disinfectants, UV light, and antibiotics, permitting long-term survival against environmental insults and efficient transmission from host to host. Although the morphological stages of spore formation are similar between C. difficile and other well-studied endospore-forming bacteria, the C. difficile genome does not appear to encode many of the known, conserved regulatory factors that are necessary to initiate sporulation in other spore-forming bacteria. The absence of early sporulation-specific orthologs suggests that C. difficile has evolved to control sporulation initiation in response "],"journal":["Current opinion in microbiology"],"pubmed_title":["Genetic mechanisms governing sporulation initiation in Clostridioides difficile."],"pmcid":["PMC9064876"],"funding_grant_id":["GM008490","AI156052","AI116933","R01 AI156052","F31 DK126467","R01 AI116933","AI106699","T32 AI106699","T32 GM008490","DK126467"],"pubmed_authors":["DiCandia MA","Vargas Cuebas GG","Monteiro MP","Lee CD","Edwards AN","McBride SM","Rizvi A"],"additional_accession":[]},"is_claimable":false,"name":"Genetic mechanisms governing sporulation initiation in Clostridioides difficile.","description":"As an anaerobe, Clostridioides difficile relies on the formation of a dormant spore for survival outside of the mammalian host's gastrointestinal tract. The spore is recalcitrant to desiccation, numerous disinfectants, UV light, and antibiotics, permitting long-term survival against environmental insults and efficient transmission from host to host. Although the morphological stages of spore formation are similar between C. difficile and other well-studied endospore-forming bacteria, the C. difficile genome does not appear to encode many of the known, conserved regulatory factors that are necessary to initiate sporulation in other spore-forming bacteria. The absence of early sporulation-specific orthologs suggests that C. difficile has evolved to control sporulation initiation in response ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-26T04:47:46.281Z","creation":"2025-04-06T11:12:56.6Z"},"accession":"S-EPMC9064876","cross_references":{"pubmed":["34933206"],"doi":["10.1016/j.mib.2021.12.001"]}}