{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(33)"],"submitter":["Yuan J"],"pubmed_abstract":["<h4>Background/aims</h4>Most recently, micro RNAs (miRNAs/miRs) have been suggested to play a key role in various physiological and pathological processes by regulating the expression of specific genes. The influence of miR-377-3p on multitudinous cancer cells has been investigated; however, its function in melanoma remains undiscovered. Armadillo repeat-containing protein 8 (ARMC8), a target of miR-377-3p, plays essential roles in proliferation, differentiation and apoptosis. Our research aimed to detect the specific roles of miR-377-3p in melanoma.<h4>Methods</h4>The MiRNA and mRNA expressions were evaluated by a real-time quantitative polymerase chain reaction in the A375 and HEMa-LP cell lines. We predicted the possible interactions between microRNA and mRNAs by bioinformatics database"],"journal":["RSC advances"],"pagination":["19057-19064"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065064"],"repository":["biostudies-literature"],"pubmed_title":["The micro RNA hsa-miR-377-3p inhibits tumor growth in malignant melanoma."],"pmcid":["PMC9065064"],"pubmed_authors":["Jiang L","Guo C","Yuan J"],"additional_accession":[]},"is_claimable":false,"name":"The micro RNA hsa-miR-377-3p inhibits tumor growth in malignant melanoma.","description":"<h4>Background/aims</h4>Most recently, micro RNAs (miRNAs/miRs) have been suggested to play a key role in various physiological and pathological processes by regulating the expression of specific genes. The influence of miR-377-3p on multitudinous cancer cells has been investigated; however, its function in melanoma remains undiscovered. Armadillo repeat-containing protein 8 (ARMC8), a target of miR-377-3p, plays essential roles in proliferation, differentiation and apoptosis. Our research aimed to detect the specific roles of miR-377-3p in melanoma.<h4>Methods</h4>The MiRNA and mRNA expressions were evaluated by a real-time quantitative polymerase chain reaction in the A375 and HEMa-LP cell lines. We predicted the possible interactions between microRNA and mRNAs by bioinformatics database","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-04-04T23:17:29.82Z","creation":"2025-04-04T23:17:29.82Z"},"accession":"S-EPMC9065064","cross_references":{"pubmed":["35516861"],"doi":["10.1039/c9ra02816a"]}}