biostudies-literatureUnknown9(33)Yuan J<h4>Background/aims</h4>Most recently, micro RNAs (miRNAs/miRs) have been suggested to play a key role in various physiological and pathological processes by regulating the expression of specific genes. The influence of miR-377-3p on multitudinous cancer cells has been investigated; however, its function in melanoma remains undiscovered. Armadillo repeat-containing protein 8 (ARMC8), a target of miR-377-3p, plays essential roles in proliferation, differentiation and apoptosis. Our research aimed to detect the specific roles of miR-377-3p in melanoma.<h4>Methods</h4>The MiRNA and mRNA expressions were evaluated by a real-time quantitative polymerase chain reaction in the A375 and HEMa-LP cell lines. We predicted the possible interactions between microRNA and mRNAs by bioinformatics databaseRSC advances19057-19064https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065064biostudies-literatureThe micro RNA hsa-miR-377-3p inhibits tumor growth in malignant melanoma.PMC9065064Jiang LGuo CYuan JfalseThe micro RNA hsa-miR-377-3p inhibits tumor growth in malignant melanoma.<h4>Background/aims</h4>Most recently, micro RNAs (miRNAs/miRs) have been suggested to play a key role in various physiological and pathological processes by regulating the expression of specific genes. The influence of miR-377-3p on multitudinous cancer cells has been investigated; however, its function in melanoma remains undiscovered. Armadillo repeat-containing protein 8 (ARMC8), a target of miR-377-3p, plays essential roles in proliferation, differentiation and apoptosis. Our research aimed to detect the specific roles of miR-377-3p in melanoma.<h4>Methods</h4>The MiRNA and mRNA expressions were evaluated by a real-time quantitative polymerase chain reaction in the A375 and HEMa-LP cell lines. We predicted the possible interactions between microRNA and mRNAs by bioinformatics database2019-01-01T00:00:00Z2019 Jun2025-04-04T23:17:29.82Z2025-04-04T23:17:29.82ZS-EPMC90650643551686110.1039/c9ra02816a