{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Muller-Eigner A"],"funding":["Impetus Grant National Natural Science Foundation of China","Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world's longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and tests its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, p"],"journal":["Communications biology"],"pagination":["408"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065075"],"repository":["biostudies-literature"],"pubmed_title":["Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse."],"pmcid":["PMC9065075"],"pubmed_authors":["Gerlini R","Becker L","Schoen J","Imhof A","Ludwig C","Koch F","Gailus-Durner V","Forne I","de Angelis MH","Klein-Rodewald T","Caton V","Venkatasubramani AV","Rathkolb B","Aguilar-Pimentel A","Heiker JT","Peleg S","Langhammer M","Calzada-Wack J","Brenmoehl J","Reyer H","Hoeflich A","Gille B","Kuhla A","Meng C","Palma-Vera S","Fuchs H","Muller-Eigner A","Sanz-Moreno A","de-Diego I"],"additional_accession":[]},"is_claimable":false,"name":"Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.","description":"Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world's longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and tests its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, p","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-31T21:00:32.185Z","creation":"2025-04-04T21:43:33.878Z"},"accession":"S-EPMC9065075","cross_references":{"pubmed":["35505192"],"doi":["10.1038/s42003-022-03339-3"]}}