{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Allen LL"],"funding":["NICHD NIH HHS","NHLBI NIH HHS","American Physiological Society","National Institutes of Health"],"pagination":["113832"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065093"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["346"],"pubmed_abstract":["Cervical spinal cord injury (cSCI) severs bulbospinal projections to respiratory motor neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a model of cSCI often used to study spontaneous and induced plasticity and breathing recovery post-injury. One key assumption is that C2Hx dennervates motor neurons below the injury, but does not affect their survival. However, a recent study reported substantial bilateral motor neuron death caudal to C2Hx. Since phrenic motor neuron (PMN) death following C2Hx would have profound implications for therapeutic strategies designed to target spared neural circuits, we tested the hypothesis that C2Hx minimally impacts PMN survival. Using improved retrograde tracing methods, we observed no loss of PMNs at 2- or 8-weeks po"],"journal":["Experimental neurology"],"pubmed_title":["Phrenic motor neuron survival below cervical spinal cord hemisection."],"pmcid":["PMC9065093"],"funding_grant_id":["K12 HD055929","R00 HL119606","R01 HL069064","HL69064","K99 HL119606","T32 HD043730","T32-HD043730","K99 / R00 HL119606"],"pubmed_authors":["Emery AT","Mitchell GS","Holland AE","Asa ZA","Santiago JV","Nichols NL","Ciesla MC","Gonzalez-Rothi EJ","Allen LL"],"additional_accession":[]},"is_claimable":false,"name":"Phrenic motor neuron survival below cervical spinal cord hemisection.","description":"Cervical spinal cord injury (cSCI) severs bulbospinal projections to respiratory motor neurons, paralyzing respiratory muscles below the injury. C2 spinal hemisection (C2Hx) is a model of cSCI often used to study spontaneous and induced plasticity and breathing recovery post-injury. One key assumption is that C2Hx dennervates motor neurons below the injury, but does not affect their survival. However, a recent study reported substantial bilateral motor neuron death caudal to C2Hx. Since phrenic motor neuron (PMN) death following C2Hx would have profound implications for therapeutic strategies designed to target spared neural circuits, we tested the hypothesis that C2Hx minimally impacts PMN survival. Using improved retrograde tracing methods, we observed no loss of PMNs at 2- or 8-weeks po","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-19T15:40:24.187Z","creation":"2025-04-19T15:40:24.187Z"},"accession":"S-EPMC9065093","cross_references":{"pubmed":["34363808"],"doi":["10.1016/j.expneurol.2021.113832"]}}