{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Vulto A"],"pubmed_abstract":["<h4>Objective</h4>To compare cortisol pharmacokinetics and pharmacodynamics mapped through several glucocorticoid sensitive pathways in patients on hydrocortisone substitution with or without an adrenal crisis.<h4>Design</h4>A <i>post-hoc</i> analysis of a previously conducted randomized controlled trial in patients with secondary adrenal insufficiency examining the effects of 2 weight-adjusted hydrocortisone doses.<h4>Methods</h4>Comparisons were primarily made on a hydrocortisone dose of 0.2-0.3 mg/kg/day for plasma cortisol and cortisone, 24-hour urinary steroid profile, the glucocorticoid sensitive tryptophan-kynurenine pathway, the renin-angiotensin-aldosterone system and aspects of quality of life. Variables of interest were also analyzed on the hydrocortisone dose of 0.4-0.6 mg/kg/d"],"journal":["Frontiers in endocrinology"],"pagination":["849188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065259"],"repository":["biostudies-literature"],"pubmed_title":["Susceptibility to Adrenal Crisis Is Associated With Differences in Cortisol Excretion in Patients With Secondary Adrenal Insufficiency."],"pmcid":["PMC9065259"],"pubmed_authors":["van Faassen M","Kerstens MN","van Beek AP","Vulto A"],"additional_accession":[]},"is_claimable":false,"name":"Susceptibility to Adrenal Crisis Is Associated With Differences in Cortisol Excretion in Patients With Secondary Adrenal Insufficiency.","description":"<h4>Objective</h4>To compare cortisol pharmacokinetics and pharmacodynamics mapped through several glucocorticoid sensitive pathways in patients on hydrocortisone substitution with or without an adrenal crisis.<h4>Design</h4>A <i>post-hoc</i> analysis of a previously conducted randomized controlled trial in patients with secondary adrenal insufficiency examining the effects of 2 weight-adjusted hydrocortisone doses.<h4>Methods</h4>Comparisons were primarily made on a hydrocortisone dose of 0.2-0.3 mg/kg/day for plasma cortisol and cortisone, 24-hour urinary steroid profile, the glucocorticoid sensitive tryptophan-kynurenine pathway, the renin-angiotensin-aldosterone system and aspects of quality of life. Variables of interest were also analyzed on the hydrocortisone dose of 0.4-0.6 mg/kg/d","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T12:14:45.182Z","creation":"2025-04-06T21:54:04.348Z"},"accession":"S-EPMC9065259","cross_references":{"pubmed":["35518935"],"doi":["10.3389/fendo.2022.849188"]}}