biostudies-literatureUnknown9(35)Bordoni CA microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5'-phosphoramidate synthesis, without protection of the 3' position in the ribonucleoside.RSC advances20113-20117https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065484biostudies-literatureMicrowave-assisted organic synthesis of nucleoside ProTide analogues.PMC9065484Costantino GBrancale ACima CMBordoni CAzzali EfalseMicrowave-assisted organic synthesis of nucleoside ProTide analogues.A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5'-phosphoramidate synthesis, without protection of the 3' position in the ribonucleoside.2019-01-01T00:00:00Z2019 Jun2025-04-22T07:46:31.087Z2025-04-05T22:19:15.069ZS-EPMC90654843551471810.1039/c9ra01754b