biostudies-literatureSafaei-Ghomi JUniversity of Kashan19662-19674https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065583biostudies-literatureUnknown9(34)We used a novel hybrid catalyst in chemo-, regio-, and diastereoselective multi-component reactions (MCR) for the synthesis of the 2-aza analogue of pyrrolizidine and spirooxindole-2-azapyrrolizidine derivatives. The nanocatalyst, W(iv)/NNBIA-SBA-15 [where NNBIA = <i>N</i>,<i>N</i>'-(ethane-1,2-diyl)bis(2-aminobenzamide)] was synthesized by covalent grafting on chloro-functionalized SBA-15. The synthesis process was followed by the anchoring of WCl₆ to catch the desired catalyst. The quality of the catalyst was assessed using different analytical techniques such as X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FT-IR), N₂ adsorption analysis, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), enRSC advancesTungsten anchored onto functionalized SBA-15: an efficient catalyst for diastereoselective synthesis of 2-azapyrrolizidine alkaloid scaffolds.PMC9065583159148/73Bakhtiari ASafaei-Ghomi JfalseTungsten anchored onto functionalized SBA-15: an efficient catalyst for diastereoselective synthesis of 2-azapyrrolizidine alkaloid scaffolds.We used a novel hybrid catalyst in chemo-, regio-, and diastereoselective multi-component reactions (MCR) for the synthesis of the 2-aza analogue of pyrrolizidine and spirooxindole-2-azapyrrolizidine derivatives. The nanocatalyst, W(iv)/NNBIA-SBA-15 [where NNBIA = <i>N</i>,<i>N</i>'-(ethane-1,2-diyl)bis(2-aminobenzamide)] was synthesized by covalent grafting on chloro-functionalized SBA-15. The synthesis process was followed by the anchoring of WCl₆ to catch the desired catalyst. The quality of the catalyst was assessed using different analytical techniques such as X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FT-IR), N₂ adsorption analysis, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), en2019-01-01T00:00:00Z2019 Jun2025-04-22T07:47:53.678Z2025-04-05T22:18:46.374ZS-EPMC90655833551937510.1039/c9ra02825k