{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Romano A"],"funding":["A.I.L. Sezione di Catania","Università di Catania","Fon.Ca.Ne.Sa"],"pagination":["7237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065667"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Since neutrophil extracellular traps formation (NET-osis) can be assessed indirectly by treating healthy neutrophils with blood-derived fluids from patients and then measuring the NETs response, we designed a pilot study to convey high-dimensional cytometry of peripheral blood immune cells and cytokines, combined with clinical features, to understand if NET-osis assessment could be included in the immune risk profiling to early prediction of clinical patterns, disease severity, and viral clearance at 28 days in COVID-19 patients. Immune cells composition of peripheral blood, cytokines concentration and in-vitro NETosis were detected in peripheral blood of 41 consecutive COVID-19 inpatients, including 21 mild breakthrough infections compared to 20 healthy donors, matched for sex and age. Ma"],"journal":["Scientific reports"],"pubmed_title":["In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection."],"pmcid":["PMC9065667"],"funding_grant_id":["Piano per la Ricerca 2018-2020 PIACERI"],"pubmed_authors":["Di Raimondo F","Manuele R","Botta C","Montineri A","Giallongo C","Volti GL","Barbato A","Palumbo GA","Agodi A","Romano A","Puglisi F","La Ferla L","Iacobello C","Triolo AM","Tibullo D","Parrinello NL","Barchitta M","Siragusa S","Maugeri A"],"additional_accession":[]},"is_claimable":false,"name":"In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection.","description":"Since neutrophil extracellular traps formation (NET-osis) can be assessed indirectly by treating healthy neutrophils with blood-derived fluids from patients and then measuring the NETs response, we designed a pilot study to convey high-dimensional cytometry of peripheral blood immune cells and cytokines, combined with clinical features, to understand if NET-osis assessment could be included in the immune risk profiling to early prediction of clinical patterns, disease severity, and viral clearance at 28 days in COVID-19 patients. Immune cells composition of peripheral blood, cytokines concentration and in-vitro NETosis were detected in peripheral blood of 41 consecutive COVID-19 inpatients, including 21 mild breakthrough infections compared to 20 healthy donors, matched for sex and age. Ma","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-06-01T02:57:21.778Z","creation":"2024-11-15T17:02:30.314Z"},"accession":"S-EPMC9065667","cross_references":{"pubmed":["35508575"],"doi":["10.1038/s41598-022-11157-0"]}}