biostudies-literatureUnknown9(36)Zhang GpH/redox sensitive, dual drug loaded nanoparticles were prepared from poly(ethylene glycol)-<i>block</i>-poly(l-lysine) (PEG-<i>b</i>-PLL) for improving cancer therapy. Platinum(iv) and <i>cis</i>-aconitic anhydride-doxorubicin (CAD) were anchored to lysine residual amine groups of PLL to form polymer prodrug conjugates, which then self-assembled into nanoparticles with hydrophobic platinum(iv) prodrugs and CAD as the core. The nanoparticles were stable in neutral environments, but once under acidic and reductive conditions, the drugs were rapidly released. The dual-loaded nanoparticles had comparable intracellular toxicity to the regimen of combined application of free cisplatin and doxorubicin.RSC advances20513-20517https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065746biostudies-literaturepH/redox sensitive nanoparticles with platinum(iv) prodrugs and doxorubicin enhance chemotherapy in ovarian cancer.PMC9065746Zhang GZhu YZhang ZWei DZheng LXiao HWang YBai HWu YfalsepH/redox sensitive nanoparticles with platinum(iv) prodrugs and doxorubicin enhance chemotherapy in ovarian cancer.pH/redox sensitive, dual drug loaded nanoparticles were prepared from poly(ethylene glycol)-<i>block</i>-poly(l-lysine) (PEG-<i>b</i>-PLL) for improving cancer therapy. Platinum(iv) and <i>cis</i>-aconitic anhydride-doxorubicin (CAD) were anchored to lysine residual amine groups of PLL to form polymer prodrug conjugates, which then self-assembled into nanoparticles with hydrophobic platinum(iv) prodrugs and CAD as the core. The nanoparticles were stable in neutral environments, but once under acidic and reductive conditions, the drugs were rapidly released. The dual-loaded nanoparticles had comparable intracellular toxicity to the regimen of combined application of free cisplatin and doxorubicin.2019-01-01T00:00:00Z2019 Jul2025-04-18T14:14:34.575Z2025-04-07T00:17:34.79ZS-EPMC90657463551555610.1039/c9ra04034j