{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["80"],"submitter":["Luo Z"],"pubmed_abstract":["<h4>Background</h4>In HIV infection, even under long-term antiretroviral therapy (ART), up to 20% of HIV-infected individuals fail to restore CD4+ T cell counts to the levels similar to those of healthy controls. The mechanisms of poor CD4+ T cell reconstitution on suppressive ART are not fully understood.<h4>Methods</h4>Here, we tested the hypothesis that lipopolysaccharide (LPS) from bacteria enriched in the plasma from immune non-responders (INRs) contributes to blunted CD4+ T cell recovery on suppressive ART in HIV. We characterized plasma microbiome in HIV INRs (aviremic, CD4+ T cell counts < 350 cells/μl), immune responders (IRs, CD4+ T cell counts > 500 cells/μl), and healthy controls. Next, we analyzed the structure of the lipid A domain of three bacterial species identified by mas"],"journal":["EBioMedicine"],"pagination":["104037"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9065923"],"repository":["biostudies-literature"],"pubmed_title":["Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV."],"pmcid":["PMC9065923"],"pubmed_authors":["Yang H","Martin JN","Luo Z","Jiang W","Scott A","Collins M","Health SL","Li M","Wu Y","Deeks SG"],"additional_accession":[]},"is_claimable":false,"name":"Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV.","description":"<h4>Background</h4>In HIV infection, even under long-term antiretroviral therapy (ART), up to 20% of HIV-infected individuals fail to restore CD4+ T cell counts to the levels similar to those of healthy controls. The mechanisms of poor CD4+ T cell reconstitution on suppressive ART are not fully understood.<h4>Methods</h4>Here, we tested the hypothesis that lipopolysaccharide (LPS) from bacteria enriched in the plasma from immune non-responders (INRs) contributes to blunted CD4+ T cell recovery on suppressive ART in HIV. We characterized plasma microbiome in HIV INRs (aviremic, CD4+ T cell counts < 350 cells/μl), immune responders (IRs, CD4+ T cell counts > 500 cells/μl), and healthy controls. Next, we analyzed the structure of the lipid A domain of three bacterial species identified by mas","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T21:31:34.265Z","creation":"2025-02-19T03:27:44.745Z"},"accession":"S-EPMC9065923","cross_references":{"pubmed":["35500539"],"doi":["10.1016/j.ebiom.2022.104037"]}}