{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Joung JY"],"funding":["Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries"],"pubmed_abstract":["This study investigated the effects of a synbiotic combination (Syn) of <i>Lactobacillus gasseri</i> 505 (505) and <i>Cudrania tricuspidata</i> leaf extract (CT) on the hypothalamic-pituitary-gonadal axis in mice under chronic stress. Unpredictable chronic mild stress (UCMS) significantly increased the serum levels of corticosterone, however, treatment with Syn suppressed UCMS-induced increases. Histopathological analysis of the testes showed that these organs experienced some damage during UCMS, but this was repaired following treatment with Syn. Similarly, the transcription levels of gonadotropin-releasing hormone (<i>GnRH</i>), GnRH receptor, and gonadotropins, moreover, testicular development (i.e., <i>Adam5</i>, <i>Adam29</i>, and <i>Spam1</i>) - and steroidogenesis (i.e., <i>Lhr</i>,"],"journal":["Frontiers in endocrinology"],"pagination":["835033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9066698"],"repository":["biostudies-literature"],"pubmed_title":["A Synbiotic Combination of <i>Lactobacillus gasseri</i> 505 and <i>Cudrania tricuspidata</i> Leaf Extract Prevents Stress-Induced Testicular Dysfunction in Mice."],"pmcid":["PMC9066698"],"pubmed_authors":["Seo YJ","Kim SH","Oh NS","Lim W","Joung JY","Ham J"],"additional_accession":[]},"is_claimable":false,"name":"A Synbiotic Combination of <i>Lactobacillus gasseri</i> 505 and <i>Cudrania tricuspidata</i> Leaf Extract Prevents Stress-Induced Testicular Dysfunction in Mice.","description":"This study investigated the effects of a synbiotic combination (Syn) of <i>Lactobacillus gasseri</i> 505 (505) and <i>Cudrania tricuspidata</i> leaf extract (CT) on the hypothalamic-pituitary-gonadal axis in mice under chronic stress. Unpredictable chronic mild stress (UCMS) significantly increased the serum levels of corticosterone, however, treatment with Syn suppressed UCMS-induced increases. Histopathological analysis of the testes showed that these organs experienced some damage during UCMS, but this was repaired following treatment with Syn. Similarly, the transcription levels of gonadotropin-releasing hormone (<i>GnRH</i>), GnRH receptor, and gonadotropins, moreover, testicular development (i.e., <i>Adam5</i>, <i>Adam29</i>, and <i>Spam1</i>) - and steroidogenesis (i.e., <i>Lhr</i>,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T05:44:34.943Z","creation":"2025-04-05T21:28:29.666Z"},"accession":"S-EPMC9066698","cross_references":{"pubmed":["35518925"],"doi":["10.3389/fendo.2022.835033"]}}