biostudies-literatureUnknown13Joung JYKorea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and FisheriesThis study investigated the effects of a synbiotic combination (Syn) of <i>Lactobacillus gasseri</i> 505 (505) and <i>Cudrania tricuspidata</i> leaf extract (CT) on the hypothalamic-pituitary-gonadal axis in mice under chronic stress. Unpredictable chronic mild stress (UCMS) significantly increased the serum levels of corticosterone, however, treatment with Syn suppressed UCMS-induced increases. Histopathological analysis of the testes showed that these organs experienced some damage during UCMS, but this was repaired following treatment with Syn. Similarly, the transcription levels of gonadotropin-releasing hormone (<i>GnRH</i>), GnRH receptor, and gonadotropins, moreover, testicular development (i.e., <i>Adam5</i>, <i>Adam29</i>, and <i>Spam1</i>) - and steroidogenesis (i.e., <i>Lhr</i>,Frontiers in endocrinology835033https://www.ebi.ac.uk/biostudies/studies/S-EPMC9066698biostudies-literatureA Synbiotic Combination of <i>Lactobacillus gasseri</i> 505 and <i>Cudrania tricuspidata</i> Leaf Extract Prevents Stress-Induced Testicular Dysfunction in Mice.PMC9066698Seo YJKim SHOh NSLim WJoung JYHam JfalseA Synbiotic Combination of <i>Lactobacillus gasseri</i> 505 and <i>Cudrania tricuspidata</i> Leaf Extract Prevents Stress-Induced Testicular Dysfunction in Mice.This study investigated the effects of a synbiotic combination (Syn) of <i>Lactobacillus gasseri</i> 505 (505) and <i>Cudrania tricuspidata</i> leaf extract (CT) on the hypothalamic-pituitary-gonadal axis in mice under chronic stress. Unpredictable chronic mild stress (UCMS) significantly increased the serum levels of corticosterone, however, treatment with Syn suppressed UCMS-induced increases. Histopathological analysis of the testes showed that these organs experienced some damage during UCMS, but this was repaired following treatment with Syn. Similarly, the transcription levels of gonadotropin-releasing hormone (<i>GnRH</i>), GnRH receptor, and gonadotropins, moreover, testicular development (i.e., <i>Adam5</i>, <i>Adam29</i>, and <i>Spam1</i>) - and steroidogenesis (i.e., <i>Lhr</i>,2022-01-01T00:00:00Z20222025-04-22T05:44:34.943Z2025-04-05T21:28:29.666ZS-EPMC90666983551892510.3389/fendo.2022.835033