{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Yu S"],"pubmed_abstract":["<h4>Background</h4>Microcystic adnexal carcinoma (MAC) is a skin cancer with challenges in diagnosis and management. This study was aimed to detect molecular alterations of MAC and guide its pathologic diagnosis and treatment.<h4>Methods</h4>We performed transcriptome analysis on 5 MAC and 5 normal skin tissues, identified the differentially expressed genes, and verified them by immunohistochemistry.<h4>Results</h4>Three hundred four differentially expressed genes (DEGs) in MAC were identified by next-generation transcriptome sequencing, among which 225 genes were upregulated and 79 genes were downregulated. Four genes of the calcium signaling pathway, including calcium voltage-gated channel subunit alpha 1 S (CACNA1S), ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 (ATP2A1)"],"journal":["World journal of surgical oncology"],"pagination":["142"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9066904"],"repository":["biostudies-literature"],"pubmed_title":["Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation."],"pmcid":["PMC9066904"],"pubmed_authors":["Liu X","Song L","Yu S","Tang B","Zhu H","Wang Y","Sun H","Xu G"],"additional_accession":[]},"is_claimable":false,"name":"Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation.","description":"<h4>Background</h4>Microcystic adnexal carcinoma (MAC) is a skin cancer with challenges in diagnosis and management. This study was aimed to detect molecular alterations of MAC and guide its pathologic diagnosis and treatment.<h4>Methods</h4>We performed transcriptome analysis on 5 MAC and 5 normal skin tissues, identified the differentially expressed genes, and verified them by immunohistochemistry.<h4>Results</h4>Three hundred four differentially expressed genes (DEGs) in MAC were identified by next-generation transcriptome sequencing, among which 225 genes were upregulated and 79 genes were downregulated. Four genes of the calcium signaling pathway, including calcium voltage-gated channel subunit alpha 1 S (CACNA1S), ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 (ATP2A1)","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-26T15:21:45.737Z","creation":"2025-04-06T14:51:02.862Z"},"accession":"S-EPMC9066904","cross_references":{"pubmed":["35509066"],"doi":["10.1186/s12957-022-02601-6"]}}