{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China","National Key R&amp;D program of China"],"pagination":["198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9066907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Serine/arginine-rich splicing factor 9 (SRSF9) is a classical RNA-binding protein that is essential for regulating gene expression programs through its interaction with target RNA. Whether SRSF9 plays an essential role in colorectal cancer (CRC) progression and can serve as a therapeutic target is largely unknown. Here, we highlight new findings on the role of SRSF9 in CRC progression and elucidate the underlying mechanism.<h4>Methods</h4>CRC cell lines and clinical tissue samples were used. qRT-PCR, Western blotting, immunohistochemistry (IHC), gain- and loss-of-function assays, animal xenograft model studies, bioinformatic analysis, methylated single-stranded RNA affinity assays, gene-specific m6A quantitative qRT-PCR, dual-luciferase reporter assays and RNA stability "],"journal":["Journal of translational medicine"],"pubmed_title":["SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner."],"pmcid":["PMC9066907"],"funding_grant_id":["2017A030313607","2016A030313580","82173298","81672441","2017YFC1309002"],"pubmed_authors":["Chen Q","Tang M","Wang P","Xiong L","Lu X","Lin X","Liang L","Wang X","Lin J","Shi K","Hong C"],"additional_accession":[]},"is_claimable":false,"name":"SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner.","description":"<h4>Background</h4>Serine/arginine-rich splicing factor 9 (SRSF9) is a classical RNA-binding protein that is essential for regulating gene expression programs through its interaction with target RNA. Whether SRSF9 plays an essential role in colorectal cancer (CRC) progression and can serve as a therapeutic target is largely unknown. Here, we highlight new findings on the role of SRSF9 in CRC progression and elucidate the underlying mechanism.<h4>Methods</h4>CRC cell lines and clinical tissue samples were used. qRT-PCR, Western blotting, immunohistochemistry (IHC), gain- and loss-of-function assays, animal xenograft model studies, bioinformatic analysis, methylated single-stranded RNA affinity assays, gene-specific m6A quantitative qRT-PCR, dual-luciferase reporter assays and RNA stability ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-31T01:01:13.597Z","creation":"2025-04-04T22:09:04.661Z"},"accession":"S-EPMC9066907","cross_references":{"pubmed":["35509101"],"doi":["10.1186/s12967-022-03399-3"]}}