{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(9)"],"submitter":["Chebly A"],"funding":["Ligue Contre le Cancer","Société Française de Dermatologie et de Pathologie Sexuellement Transmissible","Centre National de la Recherche Scientifique","Institut National de la Santé et de la Recherche Médicale"],"pubmed_abstract":["Cutaneous T-cell lymphomas (CTCLs) are telomerase-positive tumors expressing hTERT, although neither gene rearrangement/amplification nor promoter hotspot mutations could explain the hTERT re-expression. As the hTERT promoter is rich in CpG, we investigated the contribution of epigenetic mechanisms in its re-expression. We analyzed hTERT promoter methylation status in CTCL cells compared with healthy cells. Gene-specific methylation analyses revealed a common methylation pattern exclusively in tumor cells. This methylation pattern encompassed a hypermethylated distal region from -650 to -150 bp and a hypomethylated proximal region from -150 to +150 bp. Interestingly, the hypermethylated region matches with the recently named TERT hypermethylated oncogenic region (THOR). THOR has been assoc"],"journal":["Molecular oncology"],"pagination":["1931-1946"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9067155"],"repository":["biostudies-literature"],"pubmed_title":["Exploring hTERT promoter methylation in cutaneous T-cell lymphomas."],"pmcid":["PMC9067155"],"pubmed_authors":["Segal-Bendirdjian E","Pham-Ledard A","Chouery E","Tomb R","Poglio S","Prochazkova-Carlotti M","Idrissi Y","Ropio J","Beylot-Barry M","Ferrer J","Merlio JP","Chebly A","Chevret E","Peloponese JM","Cherrier F","Farra C"],"additional_accession":[]},"is_claimable":false,"name":"Exploring hTERT promoter methylation in cutaneous T-cell lymphomas.","description":"Cutaneous T-cell lymphomas (CTCLs) are telomerase-positive tumors expressing hTERT, although neither gene rearrangement/amplification nor promoter hotspot mutations could explain the hTERT re-expression. As the hTERT promoter is rich in CpG, we investigated the contribution of epigenetic mechanisms in its re-expression. We analyzed hTERT promoter methylation status in CTCL cells compared with healthy cells. Gene-specific methylation analyses revealed a common methylation pattern exclusively in tumor cells. This methylation pattern encompassed a hypermethylated distal region from -650 to -150 bp and a hypomethylated proximal region from -150 to +150 bp. Interestingly, the hypermethylated region matches with the recently named TERT hypermethylated oncogenic region (THOR). THOR has been assoc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-18T15:44:38.627Z","creation":"2025-02-19T04:21:18.202Z"},"accession":"S-EPMC9067155","cross_references":{"pubmed":["33715271"],"doi":["10.1002/1878-0261.12946"]}}