{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(40)"],"submitter":["Shimizu M"],"funding":["Ministry of Education, Culture, Sports, Science and Technology","Japan Society for the Promotion of Science"],"pubmed_abstract":["Alkylation of iminomalonate with Grignard reagents followed by oxidation and allylation gave symmetrical quaternary α-amino diesters in good yields. Subsequent desymmetrization of a diol derivative from these products was conducted <i>via</i> asymmetric carbamylation catalyzed by Cu-Bnbox to give chiral quaternary aminodiol mono-carbamates."],"journal":["RSC advances"],"pagination":["23400-23407"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9067299"],"repository":["biostudies-literature"],"pubmed_title":["Double nucleophilic addition to iminomalonate, leading to the synthesis of quaternary α-amino diesters and desymmetrization of the products."],"pmcid":["PMC9067299"],"pubmed_authors":["Shimizu M","Mushika M","Zhu Y","Mizota I"],"additional_accession":[]},"is_claimable":false,"name":"Double nucleophilic addition to iminomalonate, leading to the synthesis of quaternary α-amino diesters and desymmetrization of the products.","description":"Alkylation of iminomalonate with Grignard reagents followed by oxidation and allylation gave symmetrical quaternary α-amino diesters in good yields. Subsequent desymmetrization of a diol derivative from these products was conducted <i>via</i> asymmetric carbamylation catalyzed by Cu-Bnbox to give chiral quaternary aminodiol mono-carbamates.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-26T04:36:09.336Z","creation":"2025-04-06T11:11:49.063Z"},"accession":"S-EPMC9067299","cross_references":{"pubmed":["35514493"],"doi":["10.1039/c9ra04889h"]}}