biostudies-literatureUnknown9(40)Shimizu MMinistry of Education, Culture, Sports, Science and TechnologyJapan Society for the Promotion of ScienceAlkylation of iminomalonate with Grignard reagents followed by oxidation and allylation gave symmetrical quaternary α-amino diesters in good yields. Subsequent desymmetrization of a diol derivative from these products was conducted <i>via</i> asymmetric carbamylation catalyzed by Cu-Bnbox to give chiral quaternary aminodiol mono-carbamates.RSC advances23400-23407https://www.ebi.ac.uk/biostudies/studies/S-EPMC9067299biostudies-literatureDouble nucleophilic addition to iminomalonate, leading to the synthesis of quaternary α-amino diesters and desymmetrization of the products.PMC9067299Shimizu MMushika MZhu YMizota IfalseDouble nucleophilic addition to iminomalonate, leading to the synthesis of quaternary α-amino diesters and desymmetrization of the products.Alkylation of iminomalonate with Grignard reagents followed by oxidation and allylation gave symmetrical quaternary α-amino diesters in good yields. Subsequent desymmetrization of a diol derivative from these products was conducted <i>via</i> asymmetric carbamylation catalyzed by Cu-Bnbox to give chiral quaternary aminodiol mono-carbamates.2019-01-01T00:00:00Z2019 Jul2025-04-26T04:36:09.336Z2025-04-06T11:11:49.063ZS-EPMC90672993551449310.1039/c9ra04889h