{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Subbarayan K"],"funding":["Wilhelm Sander-Stiftung","Deutsche Forschungsgemeinschaft","Deutsche Krebshilfe"],"pubmed_abstract":["The extracellular matrix component biglycan (BGN) plays an essential role in various physiological and pathophysiological processes. A deficient BGN expression associated with reduced immunogenicity was found in HER-2/neu-overexpressing cells. To determine whether BGN is suppressed by oncogene-driven regulatory networks, the expression and function of BGN was analyzed in murine and human BGN<sup>low</sup>/BGN<sup>high</sup> K-RAS<sup>G12V</sup>-transformed model systems as well as in different patients' datasets of colorectal carcinoma (CRC) lesions. K-RAS-mutated CRC tissues expressed low BGN mRNA and protein levels when compared to normal colon epithelial cells, which was associated with a reduced patients' survival. Transfection of BGN in murine and human BGN<sup>low</sup> K-RAS-express"],"journal":["Oncoimmunology"],"pagination":["2069214"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9067524"],"repository":["biostudies-literature"],"pubmed_title":["Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells."],"pmcid":["PMC9067524"],"pubmed_authors":["Subbarayan K","Massa C","Steven A","Wickenhauser C","Bethmann D","Biehl K","Seliger B","Leisz S"],"additional_accession":[]},"is_claimable":false,"name":"Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.","description":"The extracellular matrix component biglycan (BGN) plays an essential role in various physiological and pathophysiological processes. A deficient BGN expression associated with reduced immunogenicity was found in HER-2/neu-overexpressing cells. To determine whether BGN is suppressed by oncogene-driven regulatory networks, the expression and function of BGN was analyzed in murine and human BGN<sup>low</sup>/BGN<sup>high</sup> K-RAS<sup>G12V</sup>-transformed model systems as well as in different patients' datasets of colorectal carcinoma (CRC) lesions. K-RAS-mutated CRC tissues expressed low BGN mRNA and protein levels when compared to normal colon epithelial cells, which was associated with a reduced patients' survival. Transfection of BGN in murine and human BGN<sup>low</sup> K-RAS-express","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T04:38:02.876Z","creation":"2025-04-06T11:12:29.271Z"},"accession":"S-EPMC9067524","cross_references":{"pubmed":["35529675"],"doi":["10.1080/2162402X.2022.2069214"]}}