biostudies-literatureUnknown11(1)Subbarayan KWilhelm Sander-StiftungDeutsche ForschungsgemeinschaftDeutsche KrebshilfeThe extracellular matrix component biglycan (BGN) plays an essential role in various physiological and pathophysiological processes. A deficient BGN expression associated with reduced immunogenicity was found in HER-2/neu-overexpressing cells. To determine whether BGN is suppressed by oncogene-driven regulatory networks, the expression and function of BGN was analyzed in murine and human BGN^low/BGN^high K-RAS^G12V-transformed model systems as well as in different patients' datasets of colorectal carcinoma (CRC) lesions. K-RAS-mutated CRC tissues expressed low BGN mRNA and protein levels when compared to normal colon epithelial cells, which was associated with a reduced patients' survival. Transfection of BGN in murine and human BGN^low K-RAS-expressOncoimmunology2069214https://www.ebi.ac.uk/biostudies/studies/S-EPMC9067524biostudies-literatureBiglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.PMC9067524Subbarayan KMassa CSteven AWickenhauser CBethmann DBiehl KSeliger BLeisz SfalseBiglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.The extracellular matrix component biglycan (BGN) plays an essential role in various physiological and pathophysiological processes. A deficient BGN expression associated with reduced immunogenicity was found in HER-2/neu-overexpressing cells. To determine whether BGN is suppressed by oncogene-driven regulatory networks, the expression and function of BGN was analyzed in murine and human BGN^low/BGN^high K-RAS^G12V-transformed model systems as well as in different patients' datasets of colorectal carcinoma (CRC) lesions. K-RAS-mutated CRC tissues expressed low BGN mRNA and protein levels when compared to normal colon epithelial cells, which was associated with a reduced patients' survival. Transfection of BGN in murine and human BGN^low K-RAS-express2022-01-01T00:00:00Z20222025-04-26T04:38:02.876Z2025-04-06T11:12:29.271ZS-EPMC90675243552967510.1080/2162402X.2022.2069214