biostudies-literatureScoggin KDefense Advanced Research Projects Agencye1010075https://www.ebi.ac.uk/biostudies/studies/S-EPMC9067680biostudies-literatureUnknown18(4)Salmonella infections typically cause self-limiting gastroenteritis, but in some individuals these bacteria can spread systemically and cause disseminated disease. Salmonella Typhimurium (STm), which causes severe systemic disease in most inbred mice, has been used as a model for disseminated disease. To screen for new infection phenotypes across a range of host genetics, we orally infected 32 Collaborative Cross (CC) mouse strains with STm and monitored their disease progression for seven days by telemetry. Our data revealed a broad range of phenotypes across CC strains in many parameters including survival, bacterial colonization, tissue damage, complete blood counts (CBC), and serum cytokines. Eighteen CC strains survived to day 7, while fourteen susceptible strains succumbed to infectiPLoS geneticsGenetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.PMC9067680D17AP00004Adams LGBowden CPeterson ALynch RAminian MSheffield MKirby MNagarajan AScoggin KThreadgill DWGupta JElsaadi AAndrews-Polymenis HLfalseGenetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.Salmonella infections typically cause self-limiting gastroenteritis, but in some individuals these bacteria can spread systemically and cause disseminated disease. Salmonella Typhimurium (STm), which causes severe systemic disease in most inbred mice, has been used as a model for disseminated disease. To screen for new infection phenotypes across a range of host genetics, we orally infected 32 Collaborative Cross (CC) mouse strains with STm and monitored their disease progression for seven days by telemetry. Our data revealed a broad range of phenotypes across CC strains in many parameters including survival, bacterial colonization, tissue damage, complete blood counts (CBC), and serum cytokines. Eighteen CC strains survived to day 7, while fourteen susceptible strains succumbed to infecti2022-01-01T00:00:00Z2022 Apr2025-04-26T15:20:02.35Z2025-04-06T14:49:39.654ZS-EPMC90676803541745410.1371/journal.pgen.1010075