biostudies-literatureMu QTechnology Innovation and Development1106353https://www.ebi.ac.uk/biostudies/studies/S-EPMC9068285biostudies-literatureUnknown2022As the representatives of closely related Chinese medicinal materials (CMMs) originated from Rutaceae family, <i>Aurantii fructus immaturus</i> (AFI), <i>Aurantii fructus</i> (AF), <i>Citri reticulatae pericarpium viride</i> (CRPV), and <i>Citri reticulatae pericarpium</i> (CRP) have better functions in regulating qi and promoting gastrointestinal motility. However, differences in the quality of closely related <i>Citrus</i> CMMs have not yet been revealed until now. Herein, this study focused on the systematic differentiation and in-depth understanding of closely related <i>Citrus</i> CMMs by a strategy integrating chemometrics and network pharmacology. Determined by ultra performance liquid chromatography, the content of nine flavonoids showed obvious fluctuations in the decoction piecesEvidence-based complementary and alternative medicine : eCAMStudy on Closely Related <i>Citrus</i> CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis.PMC90682852018ZD02Liu JLi YZhang YCui YWang YMu QChai XYu HfalseStudy on Closely Related <i>Citrus</i> CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis.As the representatives of closely related Chinese medicinal materials (CMMs) originated from Rutaceae family, <i>Aurantii fructus immaturus</i> (AFI), <i>Aurantii fructus</i> (AF), <i>Citri reticulatae pericarpium viride</i> (CRPV), and <i>Citri reticulatae pericarpium</i> (CRP) have better functions in regulating qi and promoting gastrointestinal motility. However, differences in the quality of closely related <i>Citrus</i> CMMs have not yet been revealed until now. Herein, this study focused on the systematic differentiation and in-depth understanding of closely related <i>Citrus</i> CMMs by a strategy integrating chemometrics and network pharmacology. Determined by ultra performance liquid chromatography, the content of nine flavonoids showed obvious fluctuations in the decoction pieces2022-01-01T00:00:00Z20222025-04-04T23:17:24.986Z2025-04-04T23:17:24.986ZS-EPMC90682853552992110.1155/2022/1106353