{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Yang B"],"pubmed_abstract":["Current evidences indicate that both inflammation and oxidative stress contribute to the pathogenesis of sepsis-associated skeletal muscle atrophy. However, the interaction between inflammation and oxidative stress has not been completely understood in sepsis-associated skeletal muscle atrophy. Here in the present study, a murine model of sepsis has been established by cecal ligation and puncture (CLP) with wild-type and interleukin- (IL-) 6 knockout (KO) mice. Our results suggested that IL-6 KO largely attenuated skeletal muscle atrophy as reflected by reduced protein degradation, increased cross-sectional area (CSA) of myofibers, and improved muscle contractile function (all <i>P</i> < 0.05). In addition, we observed that IL-6 KO promoted the expression of peroxisome proliferator-activat"],"journal":["Oxidative medicine and cellular longevity"],"pagination":["9148246"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9068301"],"repository":["biostudies-literature"],"pubmed_title":["IL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1<i>α</i> in Septic Mice."],"pmcid":["PMC9068301"],"pubmed_authors":["Yang X","Yang B","Sun X","Shi J","Shen Y","Chen R"],"additional_accession":[]},"is_claimable":false,"name":"IL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1<i>α</i> in Septic Mice.","description":"Current evidences indicate that both inflammation and oxidative stress contribute to the pathogenesis of sepsis-associated skeletal muscle atrophy. However, the interaction between inflammation and oxidative stress has not been completely understood in sepsis-associated skeletal muscle atrophy. Here in the present study, a murine model of sepsis has been established by cecal ligation and puncture (CLP) with wild-type and interleukin- (IL-) 6 knockout (KO) mice. Our results suggested that IL-6 KO largely attenuated skeletal muscle atrophy as reflected by reduced protein degradation, increased cross-sectional area (CSA) of myofibers, and improved muscle contractile function (all <i>P</i> < 0.05). In addition, we observed that IL-6 KO promoted the expression of peroxisome proliferator-activat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T15:14:49.065Z","creation":"2024-11-20T20:31:27.526Z"},"accession":"S-EPMC9068301","cross_references":{"pubmed":["35528525"],"doi":["10.1155/2022/9148246"]}}