biostudies-literatureUnknown2022Yang BCurrent evidences indicate that both inflammation and oxidative stress contribute to the pathogenesis of sepsis-associated skeletal muscle atrophy. However, the interaction between inflammation and oxidative stress has not been completely understood in sepsis-associated skeletal muscle atrophy. Here in the present study, a murine model of sepsis has been established by cecal ligation and puncture (CLP) with wild-type and interleukin- (IL-) 6 knockout (KO) mice. Our results suggested that IL-6 KO largely attenuated skeletal muscle atrophy as reflected by reduced protein degradation, increased cross-sectional area (CSA) of myofibers, and improved muscle contractile function (all <i>P</i> < 0.05). In addition, we observed that IL-6 KO promoted the expression of peroxisome proliferator-activatOxidative medicine and cellular longevity9148246https://www.ebi.ac.uk/biostudies/studies/S-EPMC9068301biostudies-literatureIL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1<i>α</i> in Septic Mice.PMC9068301Yang XYang BSun XShi JShen YChen RfalseIL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1<i>α</i> in Septic Mice.Current evidences indicate that both inflammation and oxidative stress contribute to the pathogenesis of sepsis-associated skeletal muscle atrophy. However, the interaction between inflammation and oxidative stress has not been completely understood in sepsis-associated skeletal muscle atrophy. Here in the present study, a murine model of sepsis has been established by cecal ligation and puncture (CLP) with wild-type and interleukin- (IL-) 6 knockout (KO) mice. Our results suggested that IL-6 KO largely attenuated skeletal muscle atrophy as reflected by reduced protein degradation, increased cross-sectional area (CSA) of myofibers, and improved muscle contractile function (all <i>P</i> < 0.05). In addition, we observed that IL-6 KO promoted the expression of peroxisome proliferator-activat2022-01-01T00:00:00Z20222025-04-26T15:14:49.065Z2024-11-20T20:31:27.526ZS-EPMC90683013552852510.1155/2022/9148246