{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Ismaiel N"],"pubmed_abstract":["<b>Background and Objective:</b> Lung-protective mechanical ventilation is known to attenuate ventilator-associated lung injury (VALI), but often at the expense of hypoventilation and hypercapnia. It remains unclear whether the main mechanism by which VALI is attenuated is a product of limiting mechanical forces to the lung during ventilation, or a direct biological effect of hypercapnia. <b>Methods:</b> Acute lung injury (ALI) was induced in 60 anesthetized rats by the instillation of 1.25 M HCl into the lungs via tracheostomy. Ten rats each were randomly assigned to one of six experimental groups and ventilated for 4 h with: 1) <b>Conventional HighV</b> <sub><b>E</b></sub> <b>Normocapnia</b> (high V<sub>T</sub>, high minute ventilation, normocapnia), 2) <b>Conventional Normocapnia</b> (h"],"journal":["Frontiers in physiology"],"pagination":["814968"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9068936"],"repository":["biostudies-literature"],"pubmed_title":["Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury."],"pmcid":["PMC9068936"],"pubmed_authors":["Henzler D","Whynot S","Chappe V","Slutsky AS","Geldenhuys L","Xu Z","Ismaiel N"],"additional_accession":[]},"is_claimable":false,"name":"Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury.","description":"<b>Background and Objective:</b> Lung-protective mechanical ventilation is known to attenuate ventilator-associated lung injury (VALI), but often at the expense of hypoventilation and hypercapnia. It remains unclear whether the main mechanism by which VALI is attenuated is a product of limiting mechanical forces to the lung during ventilation, or a direct biological effect of hypercapnia. <b>Methods:</b> Acute lung injury (ALI) was induced in 60 anesthetized rats by the instillation of 1.25 M HCl into the lungs via tracheostomy. Ten rats each were randomly assigned to one of six experimental groups and ventilated for 4 h with: 1) <b>Conventional HighV</b> <sub><b>E</b></sub> <b>Normocapnia</b> (high V<sub>T</sub>, high minute ventilation, normocapnia), 2) <b>Conventional Normocapnia</b> (h","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T09:10:22.602Z","creation":"2025-04-04T09:10:22.602Z"},"accession":"S-EPMC9068936","cross_references":{"pubmed":["35530505"],"doi":["10.3389/fphys.2022.814968"]}}