biostudies-literatureUnknown12(3)Shan SMolecular targeted therapy has become an emerging promising strategy in cancer treatment, and screening the agents targeting at cancer cell specific targets is very desirable for cancer treatment. Our previous study firstly found that a secretory peroxidase of class III derived from foxtail millet bran (FMBP) exhibited excellent targeting anti-colorectal cancer (CRC) activity <i>in vivo</i> and <i>in vitro</i>, whereas its underlying target remains unclear. The highlight of present study focuses on the finding that cell surface glucose-regulated protein 78 (csGRP78) abnormally located on CRC is positively correlated with the anti-CRC effects of FMBP, indicating it serves as a potential target of FMBP against CRC. Further, we demonstrated that the combination of FMBP with the nucleotide binActa pharmaceutica Sinica. B1254-1270https://www.ebi.ac.uk/biostudies/studies/S-EPMC9069399biostudies-literaturePeroxidase from foxtail millet bran exerts anti-colorectal cancer activity <i>via</i> targeting cell-surface GRP78 to inactivate STAT3 pathway.PMC9069399Li HLi ZYin RNiu JWu CZhang LShan SShi JfalsePeroxidase from foxtail millet bran exerts anti-colorectal cancer activity <i>via</i> targeting cell-surface GRP78 to inactivate STAT3 pathway.Molecular targeted therapy has become an emerging promising strategy in cancer treatment, and screening the agents targeting at cancer cell specific targets is very desirable for cancer treatment. Our previous study firstly found that a secretory peroxidase of class III derived from foxtail millet bran (FMBP) exhibited excellent targeting anti-colorectal cancer (CRC) activity <i>in vivo</i> and <i>in vitro</i>, whereas its underlying target remains unclear. The highlight of present study focuses on the finding that cell surface glucose-regulated protein 78 (csGRP78) abnormally located on CRC is positively correlated with the anti-CRC effects of FMBP, indicating it serves as a potential target of FMBP against CRC. Further, we demonstrated that the combination of FMBP with the nucleotide bin2022-01-01T00:00:00Z2022 Mar2025-04-26T04:42:50.753Z2025-04-06T11:13:18.153ZS-EPMC90693993553013210.1016/j.apsb.2021.10.004