{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kleffman K"],"funding":["NIA NIH HHS","NCI NIH HHS","NIH HHS","NIGMS NIH HHS"],"pagination":["1314-1335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9069488"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Brain metastasis is a significant cause of morbidity and mortality in multiple cancer types and represents an unmet clinical need. The mechanisms that mediate metastatic cancer growth in the brain parenchyma are largely unknown. Melanoma, which has the highest rate of brain metastasis among common cancer types, is an ideal model to study how cancer cells adapt to the brain parenchyma. Our unbiased proteomics analysis of melanoma short-term cultures revealed that proteins implicated in neurodegenerative pathologies are differentially expressed in melanoma cells explanted from brain metastases compared with those derived from extracranial metastases. We showed that melanoma cells require amyloid beta (Aβ) for growth and survival in the brain parenchyma. Melanoma-secreted Aβ activates surroun"],"journal":["Cancer discovery"],"pubmed_title":["Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis."],"pmcid":["PMC9069488"],"funding_grant_id":["P50 CA225450","P01 CA206980","T32 CA009161","P30 CA016087","P30 CA008748","RF1 AG057593","T32 GM007308","R01 CA243446","S10 OD018338","F30 CA221068"],"pubmed_authors":["DeMattos RB","Ueberheide B","Shadaloey SAA","Osman I","Baptiste G","Rogers R","Levinson G","Wong E","Galan-Echevarria F","Karz A","Von Itter R","Floristan A","Rose IVL","Ruggles KV","Chen J","Li YM","Hernando E","Blumenberg LM","Liddelow SA","Argibay D","Dhabaria A","Kleffman K","Jour G","Wadghiri YZ","Mathews P","Vega Y Saenz de Miera EC","Tranos JA","Call M","Schneider RJ","Eskow NM"],"additional_accession":[]},"is_claimable":false,"name":"Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.","description":"Brain metastasis is a significant cause of morbidity and mortality in multiple cancer types and represents an unmet clinical need. The mechanisms that mediate metastatic cancer growth in the brain parenchyma are largely unknown. Melanoma, which has the highest rate of brain metastasis among common cancer types, is an ideal model to study how cancer cells adapt to the brain parenchyma. Our unbiased proteomics analysis of melanoma short-term cultures revealed that proteins implicated in neurodegenerative pathologies are differentially expressed in melanoma cells explanted from brain metastases compared with those derived from extracranial metastases. We showed that melanoma cells require amyloid beta (Aβ) for growth and survival in the brain parenchyma. Melanoma-secreted Aβ activates surroun","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-09T19:29:59.811Z","creation":"2025-04-19T22:48:52.925Z"},"accession":"S-EPMC9069488","cross_references":{"pubmed":["35262173"],"doi":["10.1158/2159-8290.CD-21-1006","10.1158/2159-8290.cd-21-1006"]}}